Wu Feilong, Pan Jie, Chen Mingtao, Lai Xuye, Gu Yingying, Pei Lei, Yang Lili
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health Sun Yat-sen University, Guangzhou, China.
Front Aging Neurosci. 2024 Nov 5;16:1487182. doi: 10.3389/fnagi.2024.1487182. eCollection 2024.
This study investigated the potential link between serum klotho levels and cognitive function in patients with non-alcoholic fatty liver disease (NAFLD).
Utilizing NHANES data from 2011 to 2014, the research included 356 eligible participants. NAFLD was identified with the United States Fatty Liver Index (US-FLI), and cognition was measured by various tests including the Animal Fluency Test (AFT), Digit Symbol Substitution Test (DSST), Immediate Recall Test (IRT), and Delayed Recall Test (DRT). Weighted logistic regression and restricted cubic splines were employed to analyze the relationship between klotho levels and cognitive scores.
A significant nonlinear association was observed between klotho levels and the performance in DSST and Delayed Recall Test (DRT). After controlling for confounding factors, the study found a positive association between higher serum klotho levels and improved cognitive performance in both AFT and DSST. However, there was no significant relationship between klotho levels and the IRT or DRT, regardless of whether the natural logarithm or quartile was considered.
The findings suggest that a higher serum klotho level may be positively correlated with better cognitive performance in NAFLD patients.
本研究调查了非酒精性脂肪性肝病（NAFLD）患者血清klotho水平与认知功能之间的潜在联系。
利用2011年至2014年的美国国家健康与营养检查调查（NHANES）数据，该研究纳入了356名符合条件的参与者。通过美国脂肪肝指数（US-FLI）确定NAFLD，并通过包括动物流畅性测试（AFT）、数字符号替换测试（DSST）、即时回忆测试（IRT）和延迟回忆测试（DRT）在内的各种测试来测量认知。采用加权逻辑回归和受限立方样条分析klotho水平与认知分数之间的关系。
观察到klotho水平与DSST和延迟回忆测试（DRT）的表现之间存在显著的非线性关联。在控制混杂因素后，研究发现较高的血清klotho水平与AFT和DSST中改善的认知表现呈正相关。然而，无论考虑自然对数还是四分位数，klotho水平与IRT或DRT之间均无显著关系。
研究结果表明，较高的血清klotho水平可能与NAFLD患者更好的认知表现呈正相关。
