Niu Heyuan, Li Kai Yu, Yu Tao, Zhang Maorun, Ji Zhe, Yu Ping, Yi Xianfu, Liu Gang
Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
J Multidiscip Healthc. 2024 Nov 15;17:5259-5275. doi: 10.2147/JMDH.S482543. eCollection 2024.
Precision medicine is an innovative approach that integrates genomics, clinical informatics, and proteomics to address both genetic and environmental factors in disease prevention and treatment. This bibliometric study analyzes research trends, collaboration patterns, and the unique characteristics of precision medicine across countries to inform future research directions.
A comprehensive search was conducted in the Web of Science Core Collection (1999-2022) database to identify publications related to precision medicine. The analysis of publication patterns, collaborations, institutions, authors, and research hotspots was performed utilizing Microsoft PowerPoint 2019 in conjunction with the Bibliometrix package in R.
A total of 30,777 publications on precision medicine were identified. The United States and the United Kingdom were recognized as the primary contributors, while European countries exhibited substantial collaborative efforts. Harvard University and the University of California System have played pivotal roles in advancing the field. The keywords analysis showed that in the early 2000s, "gene expression" and "personalized outcomes" were key themes. Since 2015, there's been a significant shift towards advanced technologies like artificial intelligence, machine learning, liquid biopsy, highlighting their growing importance in precision medicine. Research topics across various countries exhibit certain global similarities. However, different nations exhibit distinct thematic research focuses. China emphasizes "Informatics", "Hepatocellular Carcinoma", "Photothermal Therapy", and "Lung Adenocarcinoma", while the United States prioritizes "Informatics", "Treatment Rules", and "Consortium Guidelines". Germany and France share similar interests in particular research domains.
Precision medicine is rapidly globalizing, with significant contributions from multiple countries and emerging technologies acting as catalysts for further development. Greater international cooperation is essential to elevate the quality and impact of research. These advancements hold great potential for transforming personalized healthcare by integrating cutting-edge scientific disciplines.
精准医学是一种创新方法，它整合了基因组学、临床信息学和蛋白质组学，以应对疾病预防和治疗中的遗传和环境因素。这项文献计量学研究分析了各国精准医学的研究趋势、合作模式和独特特征，以为未来的研究方向提供参考。
在科学网核心合集（1999 - 2022年）数据库中进行全面检索，以识别与精准医学相关的出版物。利用Microsoft PowerPoint 2019结合R语言中的Bibliometrix软件包对出版物模式、合作、机构、作者和研究热点进行分析。
共识别出30777篇关于精准医学的出版物。美国和英国被认为是主要贡献者，而欧洲国家展现出了大量的合作努力。哈佛大学和加利福尼亚大学系统在推动该领域发展方面发挥了关键作用。关键词分析表明，在21世纪初，“基因表达”和“个性化结果”是关键主题。自2015年以来，出现了向人工智能、机器学习、液体活检等先进技术的重大转变，凸显了它们在精准医学中日益增长的重要性。各国的研究主题呈现出一定的全球相似性。然而，不同国家有不同的主题研究重点。中国强调“信息学”“肝细胞癌”“光热疗法”和“肺腺癌”，而美国则优先关注“信息学”“治疗规则”和“联盟指南”。德国和法国在特定研究领域有相似的兴趣。
精准医学正在迅速全球化，多个国家做出了重大贡献，新兴技术成为进一步发展的催化剂。加强国际合作对于提高研究质量和影响力至关重要。这些进展通过整合前沿科学学科，在改变个性化医疗方面具有巨大潜力。
