Geissler A H, Turnlund J R, Cohen R D
Drug Nutr Interact. 1986;4(3):275-83.
This study was designed to test the hypothesis that chlorthalidone, a diuretic used to treat hypertension, depletes body zinc enough to interfere with testosterone production and thereby cause sexual dysfunction. Serum and hair zinc, serum testosterone, and sexual function were measured in 19 middle-aged hypertensive men who had been taking chlorthalidone in average daily doses of between 11 and 50 mg per day for at least 6 months, and a control group of 31 unmedicated middle-aged normotensive men. Although the medicated group had a higher incidence of sexual dysfunction (42% as compared to 16% in the control group), use of chlorthalidone did not significantly affect serum testosterone levels. When other variables were controlled for, medicated men had significantly higher serum zinc levels, and men on the highest dosage of chlorthalidone had higher hair zinc levels than all other men. There was no significant correlation between hair zinc, serum zinc, testosterone, and sexual function. Serum zinc decreased significantly with age (p = 0.043) and with ethanol intake after controlling for age (p = 0.032). Sexual dysfunction occurred more often in older men (p = 0.002). In the unmedicated controls, prevalence of dysfunction increased slightly with increasing serum potassium levels.
用于治疗高血压的利尿剂氯噻酮会使体内锌元素大量流失，进而干扰睾酮的生成，从而导致性功能障碍。研究测定了19名中年高血压男性和31名未接受药物治疗的中年血压正常男性的血清锌和发锌、血清睾酮水平以及性功能。这19名中年高血压男性每天平均服用11至50毫克氯噻酮，且至少持续服用了6个月。尽管用药组性功能障碍的发生率更高（42%，而对照组为16%），但氯噻酮的使用并未显著影响血清睾酮水平。在控制其他变量后，用药男性的血清锌水平显著更高，服用最高剂量氯噻酮的男性发锌水平高于其他所有男性。发锌、血清锌、睾酮水平与性功能之间无显著相关性。血清锌水平随年龄增长显著下降（p = 0.043），在控制年龄因素后，随乙醇摄入量增加也显著下降（p = 0.032）。性功能障碍在老年男性中更为常见（p = 0.002）。在未接受药物治疗的对照组中，性功能障碍的患病率随血清钾水平升高略有增加。
