Rhoden Ernani Luis, Telöken Claudio, Sogari Paulo Roberto, Souto Carlos Ary Vargas
Andrology Division, Department of Urology, Santa Casa Hospital and Fundação Faculdade Federal de Ciências Médicas, Porto Alegre, Brazil.
J Urol. 2002 Apr;167(4):1745-8.
We evaluated the variation in serum testosterone in normal aging men and its relationship with erectile function.
In a study that was not community based and during a free screening program for prostate cancer 1,071 men were invited to complete a sexual activity questionnaire, that is the abridged 5-item version of the International Index of Erectile Function (IIEF-5), as a diagnostic tool for erectile dysfunction. Possible scores on the IIEF-5 are 1 to 25 and erectile dysfunction was classified into 5 categories based on the scores, namely severe-1 to 7, moderate-8 to 11, mild to moderate-12 to 16, mild-17 to 21 and none-22 to 25. Serum total testosterone was measured between 8:00 and 10:00 a.m. in all men.
Of the 1,071 men 965 (90.1%) were included in this study, of whom 88% were white and 12% were black. Mean age was 60.7 years. In this sample the prevalence of all degrees of erectile dysfunction was estimated to be 53.9%. The degree of erectile dysfunction was mild in 21.5% of cases, mild to moderate in 14.1%, moderate in 6.3% and severe in 11.9%. According to age the erectile dysfunction rate was 36.4% in the 40 to 49, 42.5% in the 50 to 59, 58.1% in the 60 to 69, 79.4% in the 70 to 79 and 100% in the 80 years and older groups (p <0.05). The variation in mean serum total testosterone in the age groups was not statistically significantly different (p >0.05). Pearson coefficients of age and total testosterone did not reveal any significant correlation (r = 0.00376, p = 0.907), similar to IIEF-5 score and total testosterone (r = 0.0163, p = 0.612). However, analysis of the variables IIEF-5 and age showed a statistically significant inverse or negative relationship (r = -0.3449, p <0.05).
Erectile dysfunction showed a clear association with aging but no consistent correlation of total testosterone with erectile condition was identified.
我们评估了正常衰老男性血清睾酮的变化及其与勃起功能的关系。
在一项非社区基础的研究中，于前列腺癌免费筛查项目期间，邀请1071名男性完成一份性活动问卷，即国际勃起功能指数（IIEF - 5）的简化5项版本，作为勃起功能障碍的诊断工具。IIEF - 5的可能得分是1至25分，根据得分将勃起功能障碍分为5类，即重度（1至7分）、中度（8至11分）、轻度至中度（12至16分）、轻度（17至21分）和无（22至25分）。在上午8:00至10:00之间测量所有男性的血清总睾酮。
1071名男性中有965名（90.1%）纳入本研究，其中88%为白人，12%为黑人。平均年龄为60.7岁。在该样本中，所有程度勃起功能障碍的患病率估计为53.9%。21.5%的病例勃起功能障碍程度为轻度，14.1%为轻度至中度，6.3%为中度，11.9%为重度。按年龄划分，40至49岁组勃起功能障碍率为36.4%，50至59岁组为42.5%，60至69岁组为58.1%，70至79岁组为79.4%，80岁及以上组为100%（p<0.05）。各年龄组血清总睾酮均值的变化无统计学显著差异（p>0.05）。年龄与总睾酮的皮尔逊系数未显示任何显著相关性（r = 0.00376，p = 0.907），IIEF - 5得分与总睾酮情况类似（r = 0.0163，p = 0.612）。然而，对IIEF - 5和年龄变量的分析显示出统计学显著的负相关关系（r = -0.3449，p<0.05）。
勃起功能障碍与衰老明显相关，但未发现总睾酮与勃起状况存在一致的相关性。
