Greco Frank A, Schell Brent R, Hanlon Eugene B
Research ServiceVA Bedford Healthcare System Bedford MA 01730 USA.
Boston Medical Center and VA Boston Healthcare System Boston MA 02118 USA.
IEEE Open J Eng Med Biol. 2024 Oct 9;6:107-112. doi: 10.1109/OJEMB.2024.3477449. eCollection 2025.
We previously demonstrated that near-infrared spectroscopy in vivo presents spectral features at 895 and 861 nm that accurately classify Alzheimer's disease, mild cognitive impairment, and age-matched control subjects. Our purpose here is to associate the 895 nm signal with [Formula: see text]-amyloid. We applied our feature selection technique to subjects with and without leptomeningeal amyloid. We developed a novel concept, optical taxonomic signal, to determine the dependence of signal on source-detector distance. Features at 891 and 768 nm discriminate between subjects with and without leptomeningeal [Formula: see text]-amyloid. The variation of optical taxonomic signal with source-detector distance indicates that both signals come from the leptomeninges and not cerebral cortex. The two features are highly correlated and likely result from the same cellular material. The discovery of an 891 nm feature that clearly depends upon the presence of [Formula: see text]-amyloid supports our hypothesis that the 895 nm feature previously discovered also reports [Formula: see text]-amyloid.
我们之前证明，体内近红外光谱在895和861纳米处呈现出光谱特征，能够准确区分阿尔茨海默病、轻度认知障碍和年龄匹配的对照受试者。我们在此的目的是将895纳米信号与β-淀粉样蛋白联系起来。我们将特征选择技术应用于有和没有软脑膜淀粉样蛋白的受试者。我们提出了一个新的概念，即光学分类信号，以确定信号对源探测器距离的依赖性。891和768纳米处的特征能够区分有和没有软脑膜β-淀粉样蛋白的受试者。光学分类信号随源探测器距离的变化表明，这两个信号均来自软脑膜而非大脑皮层。这两个特征高度相关，可能源于相同的细胞物质。发现一个明显依赖于β-淀粉样蛋白存在的891纳米特征，支持了我们之前发现的895纳米特征也能反映β-淀粉样蛋白的假设。
