Innovation and Transformation Center of Science and Technology, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, PR China.
State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi Key Lab of Sugarcane Biology, College of Agriculture, Guangxi University, Nanning, Guangxi 530005, PR China.
Microb Genom. 2024 Nov;10(11). doi: 10.1099/mgen.0.001328.
Understanding the genomic diversity and functional implications of species is crucial for elucidating their evolutionary history and biotechnological potential. Here, we present the first pan-genomic analysis of spp., combining five newly sequenced genomes with ten publicly available genomes. Our comprehensive comparative study unveiled a rich genomic landscape, identifying core genes shared among all strains and species-specific gene sets. Additionally, we identified structural variants impacting the expression of key genes, including insights into the gene involved in DNA repair and recombination processes, which exhibits a 440 bp insertion in the promoter region and a leucine-to-serine mutation in the gene body, potentially increasing spore production in the S3 strain. Overall, our study provides valuable insights into the genomic architecture and functional diversity of , paving the way for further research on its evolutionary dynamics, biotechnological applications and pharmaceutical potential.
了解物种的基因组多样性和功能意义对于阐明其进化历史和生物技术潜力至关重要。在这里，我们呈现了对 spp. 的首次泛基因组分析，将五个新测序的基因组与十个公开可用的基因组相结合。我们的全面比较研究揭示了丰富的基因组景观，确定了所有菌株和物种特异性基因集之间共享的核心基因。此外，我们还鉴定了影响关键基因表达的结构变异，包括涉及 DNA 修复和重组过程的 基因的见解，该基因在启动子区域插入了 440bp，在基因体中发生了亮氨酸到丝氨酸的突变，可能会增加 S3 菌株中的孢子产生。总体而言，我们的研究为 提供了有价值的基因组结构和功能多样性见解，为进一步研究其进化动态、生物技术应用和药物潜力铺平了道路。
