Grenier Philippe A, Arutkin Maxence, Brun Anne Laure, Métivier Anne-Cécile, Sage Edouard, Haziza Franck, Ackermann Félix, Mellot François, Vallée Alexandre
Department of Clinical Research and Innovation, Foch Hospital, Suresnes, France.
Department of Epidemiology and Public Health, Foch Hospital, Suresnes, France.
Eur J Public Health. 2025 Apr 1;35(2):342-346. doi: 10.1093/eurpub/ckae183.
Despite significant therapeutic advances, lung cancer remains the biggest killer among cancers. In France, there is no national screening program against lung cancer. Thus, in this perspective, the Foch Hospital decided to implement a pilot and clinical low-dose CT screening program to evaluate the efficiency of such screening. The purpose of this study was to describe the prevalent findings of this low-dose CT screening program. Participants were recruited in the screening program through general practitioners (GPs), pharmacists, and specialists from June 2023 to June 2024. The inclusion criteria included male or female participants aged 50 to 80 years, current smokers or former smokers who had quit less than 15 years prior, with a smoking history of over 20 pack-years. Chest CT scans were conducted at Foch Hospital using a low-dose CT protocol based on volume mode with a multi-slice scanner (≥60 slices) without contrast injection. In total, 477 participants were recruited in the CT scan screening, 235 (49%) were males with a median age of 60 years [56-67] and 35 smoke pack-years [29-44] and 242 females (51%) with a median age of 60 years [55-60] and 30 smoke pack-years [25-40]. Eight participants showed positive nodules on CT scan, as a 1.7% rate. 66.7% of diagnosed cancers were in early stages (0-I). It is feasible to implement structured lung cancer screening using low-dose CT in a real-world setting among the general population. This approach successfully identifies most early-stage cancers that could be treated curatively.
尽管在治疗方面取得了重大进展，但肺癌仍然是癌症中的头号杀手。在法国，没有针对肺癌的全国性筛查项目。因此，从这个角度来看，福煦医院决定实施一项试点临床低剂量CT筛查项目，以评估这种筛查的效果。本研究的目的是描述该低剂量CT筛查项目的常见结果。2023年6月至2024年6月期间，通过全科医生、药剂师和专科医生在筛查项目中招募参与者。纳入标准包括年龄在50至80岁之间的男性或女性参与者，当前吸烟者或戒烟时间少于15年的既往吸烟者，吸烟史超过20包年。在福煦医院使用基于容积模式的低剂量CT协议，通过多层扫描仪（≥60层）进行胸部CT扫描，不注射造影剂。总共有477名参与者被纳入CT扫描筛查，其中235名（49%）为男性，中位年龄为60岁[56 - 67]，吸烟包年数为35[29 - 44]；242名女性（51%），中位年龄为60岁[55 - 60]，吸烟包年数为30[25 - 40]。8名参与者在CT扫描中显示出阳性结节，阳性率为1.7%。66.7%的确诊癌症处于早期阶段（0 - I期）。在普通人群的现实环境中使用低剂量CT实施结构化肺癌筛查是可行的。这种方法成功地识别出了大多数可治愈的早期癌症。
