Frush D P, McNamara J O
Exp Neurol. 1986 Apr;92(1):102-13. doi: 10.1016/0014-4886(86)90128-7.
We studied the occurrence of wet dog shakes during the evolution of kindling induced by electrical stimulation of the lateral entorhinal cortex. Wet dog shakes occur with high incidence, particularly early in development of kindling. We also demonstrated that microinjection of colchicine into the hippocampus, but not into neocortex, produced a 95% suppression of wet dog shakes. We propose that the suppressive effect of colchicine is mediated by destruction of dentate granule cells. Together with evidence from other investigations, these data support the idea that activation of hippocampal neurons is essential for production of wet dog shakes induced by stimulation of the limbic system.
我们研究了在电刺激内嗅皮质诱发点燃过程中“湿狗样抖动”的发生情况。“湿狗样抖动”发生率很高，尤其是在点燃发展的早期。我们还证明，向海马体而非新皮质微量注射秋水仙碱，可使“湿狗样抖动”受到95%的抑制。我们认为秋水仙碱的抑制作用是由齿状颗粒细胞的破坏介导的。与其他研究的证据一起，这些数据支持了这样一种观点，即海马神经元的激活对于边缘系统刺激诱发的“湿狗样抖动”的产生至关重要。
