Mitchell C L, Barnes M I
Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental Health Sciences, Research Triange Park, NC 27709.
Physiol Behav. 1993 Jan;53(1):45-9. doi: 10.1016/0031-9384(93)90009-5.
Bilateral destruction of dentate granule cells in both the dorsal and ventral hippocampal formation had no effect on the threshold for hippocampal afterdischarge before or after kindling. Neither did it affect the number of stimulations required to attain kindling. However, the duration of afterdischarge was significantly longer in colchicine-lesioned animals compared to those receiving artificial cerebrospinal fluid. This was true for the threshold for afterdischarge as well as at the first and last kindling trials. These results suggest that dentate granule cells may inhibit the duration of afterdischarge induced by perforant path stimulation or that other postlesion changes occur which result in a prolongation of hippocampal afterdischarge.
双侧海马背侧和腹侧结构中的齿状颗粒细胞被破坏，对点燃前或点燃后的海马放电阈值均无影响。它也不影响达到点燃所需的刺激次数。然而，与接受人工脑脊液的动物相比，秋水仙碱损伤的动物放电后持续时间明显更长。这在放电后阈值以及首次和末次点燃试验中都是如此。这些结果表明，齿状颗粒细胞可能抑制穿通通路刺激诱导的放电后持续时间，或者发生了其他损伤后变化，导致海马放电后持续时间延长。
