Khanna A K, Laidler P, Hughes L E
Eur J Surg Oncol. 1986 Mar;12(1):9-12.
A cohort of patients followed post-operatively in the Department of Surgery at the University of Wales College of Medicine has been studied to determine whether there were specific factors associated with late recurrence of malignant melanoma. The incidence of late recurrence (beyond 5 years after primary treatment) was 6.1%, seen predominantly in females with lesions of intermediate thickness. No more specific criteria could be defined to identify this small group of melanoma patients, and which might be useful in selecting patients requiring longer term careful follow-up. Since most late recurrence is loco-regional, self-examination by the patient may be the best pragmatic approach to facilitate early diagnosis of recurrent disease without imposing a heavy burden on the follow-up services of the health system.
对威尔士大学医学院外科术后随访的一组患者进行了研究，以确定是否存在与恶性黑色素瘤晚期复发相关的特定因素。晚期复发（初次治疗后5年以上）的发生率为6.1%，主要见于中等厚度病变的女性患者。无法定义更具体的标准来识别这一小部分黑色素瘤患者，而这些标准可能有助于选择需要长期仔细随访的患者。由于大多数晚期复发是局部区域性的，患者自我检查可能是促进复发性疾病早期诊断的最佳实用方法，同时又不会给卫生系统的随访服务带来沉重负担。
