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铁死亡：疾病危害与治疗前景。

Ferroptosis-disease perils and therapeutic promise.

机构信息

Department of Biological Sciences, Columbia University, New York, NY, USA.

Department of Chemistry, Columbia University, New York, NY, USA.

出版信息

Science. 2024 Nov 22;386(6724):848-849. doi: 10.1126/science.adn7030. Epub 2024 Nov 21.

DOI:10.1126/science.adn7030
PMID:39571009
Abstract

Mechanisms of iron-dependent cell death reveal potential new targets for disease treatment.

摘要

铁依赖性细胞死亡的机制揭示了疾病治疗的潜在新靶点。

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Ferroptosis-disease perils and therapeutic promise.铁死亡：疾病危害与治疗前景。
Science. 2024 Nov 22;386(6724):848-849. doi: 10.1126/science.adn7030. Epub 2024 Nov 21.
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Energy metabolism as a regulator of ferroptosis.能量代谢作为铁死亡的调控因子。
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Iron accumulation, glutathione depletion, and lipid peroxidation must occur simultaneously during ferroptosis and are mutually amplifying events.铁积累、谷胱甘肽耗竭和脂质过氧化在铁死亡过程中必须同时发生，且是相互放大的事件。
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Protein Pept Lett. 2024;31(10):759-772. doi: 10.2174/0109298665333926240927074528.

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