Xu Zhuoran, Wang Junyi, Gao Liheng, Zhang Wenjie
Shanghai Key Laboratory of Stomatology, Department of Prosthodontics, Shanghai Ninth People's Hospital, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
ACS Biomater Sci Eng. 2024 Dec 9;10(12):7337-7351. doi: 10.1021/acsbiomaterials.4c01359. Epub 2024 Nov 21.
Alveolar bone defects caused by oral trauma, alveolar fenestration, periodontal disease, and congenital malformations can severely affect oral function and facial aesthetics. Despite the successful clinical applications of bone grafts or bone substitutes, optimal alveolar bone regeneration continues to be challenging due to the complex oral environment and its unique physiological functions. Hydrogels that serve as promising candidates for tissue regeneration are under development to meet the specific needs for increased bone regeneration capacity and improved operational efficiency in alveolar bone repair. In this review, we emphasize the considerations in hydrogel design for alveolar bone regeneration and summarize the latest applications of hydrogels in prevalent clinical diseases related to alveolar bone defects. The future perspectives and challenges for the application of hydrogels in the field of alveolar bone regeneration are also discussed. Deepening our understanding of these biomaterials will facilitate the advent of novel inventions to improve the outcome of alveolar bone tissue regeneration.
由口腔创伤、牙槽骨开窗、牙周疾病和先天性畸形引起的牙槽骨缺损会严重影响口腔功能和面部美观。尽管骨移植或骨替代物在临床应用中取得了成功，但由于复杂的口腔环境及其独特的生理功能，实现最佳的牙槽骨再生仍然具有挑战性。作为组织再生有前景的候选材料，水凝胶正在研发中，以满足牙槽骨修复中提高骨再生能力和改善操作效率的特定需求。在这篇综述中，我们强调了牙槽骨再生水凝胶设计中的注意事项，并总结了水凝胶在与牙槽骨缺损相关的常见临床疾病中的最新应用。还讨论了水凝胶在牙槽骨再生领域应用的未来前景和挑战。加深我们对这些生物材料的理解将有助于新发明的出现，以改善牙槽骨组织再生的效果。
