Pu Xiaoxiao, Liang Yuxuan, Lian Jiafang, Xu Miaoxuan, Yong Yalan, Zhang Hao, Zhang Lili, Zhang Jingfei
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, PR China.
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, PR China.
Poult Sci. 2025 Jan;104(1):104523. doi: 10.1016/j.psj.2024.104523. Epub 2024 Nov 10.
This study aimed to investigate the effects of dietary dihydroartemisinin on the growth performance, meat quality, and antioxidant capacity of broiler chickens. Four-hundred one-day-old Arbor Acres male broilers were randomly assigned to five treatment groups with eight replicates and ten birds each. All broilers were fed a basal diet containing 0, 5, 10, 20 or 40 mg/kg dihydroartemisinin. The results showed that dihydroartemisinin at 10 mg/kg quadratically increased ADG, and dihydroartemisinin at 10 and 20 mg/kg quadratically increased ADFI during the days 1-21 period. Compared to the control group, dihydroartemisinin at 10 and 20 mg/kg quadratically decreased the drip loss at 24 h. Dihydroartemisinin linearly and quadratically decreased the L* value of breast muscles. Dihydroartemisinin at 20-40 mg/kg linearly and quadratically decreased the MDA concentrations at D5 and D 7 of postmortem storage. Dihydroartemisinin linearly and quadratically increased the ABTS scavenging activity at D 7 of postmortem storage. Dietary 20 mg/kg dihydroartemisinin at 21 days and 40 mg/kg dihydroartemisinin at 42 days linearly and quadratically increased serum glutathione concentrations. Dihydroartemisinin at 5-40 mg/kg linearly increased serum total superoxide dismutase activity at 42 days. Dihydroartemisinin at 10-20 mg/kg quadratically decreased serum malondialdehyde contents at 42 days. At 21 days, 20 mg/kg dihydroartemisinin quadratically increased hepatic glutathione concentrations and catalase activities. Compared to the control group, 40 mg/kg dihydroartemisinin linearly and quadratically decreased hepatic malondialdehyde contents. At 42 days, 20 mg/kg dihydroartemisinin quadratically increased catalase activities and reduced the malondialdehyde contents in liver. Dihydroartemisinin quadratically increased the hepatic mRNA expression of Nrf2. Compared to the control group, dihydroartemisinin at 10 and 20 mg/kg quadratically induced the hepatic mRNA expression of HO-1. Dihydroartemisinin at 10-40 mg/kg linearly and quadratically increased the mRNA expression of CAT in liver. These results showed that dihydroartemisinin improved growth performance, meat quality, and antioxidant capacity of broiler chickens, especially at 10 and 20 mg/kg.
本研究旨在探讨日粮双氢青蒿素对肉鸡生长性能、肉质和抗氧化能力的影响。将400只1日龄的艾维茵雄性肉鸡随机分为5个处理组，每组8个重复，每个重复10只鸡。所有肉鸡均饲喂含0、5、10、20或40mg/kg双氢青蒿素的基础日粮。结果表明，10mg/kg双氢青蒿素使1-21日龄期间的平均日增重呈二次曲线增加，10和20mg/kg双氢青蒿素使1-21日龄期间的平均日采食量呈二次曲线增加。与对照组相比，10和20mg/kg双氢青蒿素使24h滴水损失呈二次曲线降低。双氢青蒿素使胸肌的L*值呈线性和二次曲线降低。20-40mg/kg双氢青蒿素使宰后储存第5天和第7天的丙二醛浓度呈线性和二次曲线降低。双氢青蒿素使宰后储存第7天的ABTS清除活性呈线性和二次曲线增加。日粮中20mg/kg双氢青蒿素在21日龄时和40mg/kg双氢青蒿素在42日龄时使血清谷胱甘肽浓度呈线性和二次曲线增加。5-40mg/kg双氢青蒿素使42日龄时血清总超氧化物歧化酶活性呈线性增加。10-20mg/kg双氢青蒿素使42日龄时血清丙二醛含量呈二次曲线降低。在21日龄时，20mg/kg双氢青蒿素使肝脏谷胱甘肽浓度和过氧化氢酶活性呈二次曲线增加。与对照组相比，40mg/kg双氢青蒿素使肝脏丙二醛含量呈线性和二次曲线降低。在42日龄时，20mg/kg双氢青蒿素使肝脏过氧化氢酶活性呈二次曲线增加并降低了肝脏丙二醛含量。双氢青蒿素使肝脏Nrf2mRNA表达呈二次曲线增加。与对照组相比，10和20mg/kg双氢青蒿素使肝脏HO-1mRNA表达呈二次曲线诱导。10-40mg/kg双氢青蒿素使肝脏CATmRNA表达呈线性和二次曲线增加。这些结果表明，双氢青蒿素可改善肉鸡的生长性能、肉质和抗氧化能力，尤其是在10和20mg/kg时。
