Shen DongYi, Yang Sen, Qi Cong, Yang Hong
Department of Gynaecology and Obstetrics, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China,
Clinical laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Gynecol Obstet Invest. 2024 Nov 21:1-17. doi: 10.1159/000542408.
We aimed to determine the prevalence of female infertility in 204 countries and territories from 1990 to 2019.
We evaluated the female infertility global burden between 1990 and 2019 in this systematic study.
The Global Health Data Exchange query tool (
Female infertility has a devastating impact on the physical and mental health of individuals and national fertility. However, most of the previous studies on this subject were conducted on rather small sample sizes and have certain limitations.
We examined female infertility in terms of prevalence, ASR, and DALYs across different age groups in 204 countries and territories from 1990 to 2019 using data from the Global Health Data Exchange query tool.
From 1990 to 2019, ASR and DALYs for female infertility increased globally. At the SDI quintile level, middle-SDI and high-middle-SDI countries exhibited a faster increase in the ASR of female infertility. In 2019, with the highest female infertility rate recorded among those between the ages of 30-34 years and the lowest among those between the ages of 45-49 years. In 2019, high-income North America recorded the highest proportion of primary infertility, while East Asia recorded the lowest proportion.
First, the global burden of disease (GBD) database lacks data for some countries and regions. Second, data access and quality differ across locations. Third, the causes of infertility are not comprehensive, and data on Klinefelter in GBD 2019 in relation to primary infertility were absent.
Globally, the prevalence of DALYs and age-standardized female infertility rates increased from 1990 to 2019.
我们旨在确定1990年至2019年期间204个国家和地区女性不孕症的患病率。
在这项系统性研究中，我们评估了1990年至2019年期间全球女性不孕症负担。
全球卫生数据交换查询工具（http://ghdx.healthdata.org/gbd-results-tool）和社会人口学指数（SDI）（http://ghdx.healthdata.org/data-type/estimate）提供了1990年至2019年期间204个国家和地区不同年龄组女性不孕症的年度患病率、年龄标准化患病率（ASR）和伤残调整生命年（DALY）的数据。
女性不孕症对个人身心健康和国家生育率具有毁灭性影响。然而，此前关于该主题的大多数研究样本量较小且存在一定局限性。
我们使用全球卫生数据交换查询工具的数据，研究了1990年至2019年期间204个国家和地区不同年龄组女性不孕症的患病率、ASR和DALY。
1990年至2019年期间，全球女性不孕症的ASR和DALY有所增加。在SDI五分位数水平上，中等SDI和高中等SDI国家女性不孕症的ASR增长更快。2019年，30至34岁年龄组女性不孕症发生率最高，45至49岁年龄组最低。2019年，高收入的北美地区原发性不孕症比例最高，而东亚地区最低。
第一，全球疾病负担（GBD）数据库缺乏一些国家和地区的数据。第二，不同地点的数据获取和质量存在差异。第三，不孕症病因不全面，GBD 2019中关于原发性不孕症的克兰费尔特综合征数据缺失。
从1990年到2019年，全球范围内DALY患病率和年龄标准化女性不孕症率有所上升。
