The power of three: hypofractionation, protons, and molecular imaging in glioblastoma radiotherapy.
作者信息
Mellon Eric A
机构信息
Department of Radiation Oncology and Department of Biomedical Engineering, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
出版信息
Lancet Oncol. 2024 Dec;25(12):1514-1516. doi: 10.1016/S1470-2045(24)00633-8. Epub 2024 Nov 18.
Abstract
摘要
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本文引用的文献
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Short-course hypofractionated proton beam therapy, incorporating F-DOPA PET and contrast-enhanced MRI targeting, for patients aged 65 years and older with newly diagnosed glioblastoma: a single-arm phase 2 trial.针对65岁及以上新诊断胶质母细胞瘤患者的短疗程大分割质子束治疗，联合F-DOPA PET和对比增强MRI靶向：一项单臂2期试验。
Lancet Oncol. 2024 Dec;25(12):1625-1634. doi: 10.1016/S1470-2045(24)00585-0. Epub 2024 Nov 18.
2
Integrating multi-modal imaging in radiation treatments for glioblastoma.将多模态成像技术整合到胶质母细胞瘤的放射治疗中。
Neuro Oncol. 2024 Mar 4;26(12 Suppl 2):S17-S25. doi: 10.1093/neuonc/noad187.
3
A multi-institutional pilot clinical trial of spectroscopic MRI-guided radiation dose escalation for newly diagnosed glioblastoma.一项针对新诊断胶质母细胞瘤的多机构磁共振波谱成像引导下放射剂量递增的试点临床试验。
Neurooncol Adv. 2022 Jan 27;4(1):vdac006. doi: 10.1093/noajnl/vdac006. eCollection 2022 Jan-Dec.
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A prospective phase II randomized trial of proton radiotherapy vs intensity-modulated radiotherapy for patients with newly diagnosed glioblastoma.一项质子放疗与调强放疗治疗新诊断胶质母细胞瘤患者的前瞻性 II 期随机试验。
Neuro Oncol. 2021 Aug 2;23(8):1337-1347. doi: 10.1093/neuonc/noab040.
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Proton therapy reduces the likelihood of high-grade radiation-induced lymphopenia in glioblastoma patients: phase II randomized study of protons vs photons.质子治疗降低胶质母细胞瘤患者发生高级别放射性淋巴细胞减少症的可能性：质子与光子的 II 期随机研究。
Neuro Oncol. 2021 Feb 25;23(2):284-294. doi: 10.1093/neuonc/noaa182.
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Proton beam therapy utilization in adults with primary brain tumors in the United States.美国原发性脑肿瘤成人患者的质子束治疗应用情况。
J Clin Neurosci. 2020 May;75:112-116. doi: 10.1016/j.jocn.2020.03.011. Epub 2020 Mar 14.
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A phase I/II trial of 5-fraction stereotactic radiosurgery with 5-mm margins with concurrent temozolomide in newly diagnosed glioblastoma: primary outcomes.一项新诊断的胶质母细胞瘤患者采用 5 毫米边缘 5 分数次立体定向放射外科手术联合替莫唑胺治疗的 I/II 期临床试验：主要结果。
Neuro Oncol. 2020 Aug 17;22(8):1182-1189. doi: 10.1093/neuonc/noaa019.
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Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma.短程放疗联合替莫唑胺治疗老年胶质母细胞瘤患者。
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