皮肤储存条件及给药剂量浓度对[3H]T-2毒素透过人及猴离体皮肤的影响。

Effects of skin storage conditions and concentration of applied dose on [3H]T-2 toxin penetration through excised human and monkey skin.

作者信息

Kemppainen B W, Riley R T, Pace J G, Hoerr F J

出版信息

Food Chem Toxicol. 1986 Mar;24(3):221-7. doi: 10.1016/0278-6915(86)90232-2.

Abstract

Penetration of [3H]T-2 toxin through excised human and monkey skin stored at -60 degrees C was faster than through human and monkey skin stored at 4 degrees C, respectively. The permeability of refrigerated human skin was 34% of the permeability of refrigerated monkey skin. Increasing the concentration of [3H]T-2 toxin applied to the refrigerated monkey skin increased the amount of [3H]T-2 toxin penetrating the skin and enhanced the efficiency of penetration. Metabolites of [3H]T-2 toxin were identified in the receptor fluid bathing the dermal side of the excised human and monkey skin.

摘要

储存在-60℃的人及猴离体皮肤对[3H]T-2毒素的渗透速度分别比储存在4℃的人及猴皮肤要快。冷藏人皮肤的通透性是冷藏猴皮肤通透性的34%。增加施加于冷藏猴皮肤上的[3H]T-2毒素浓度，可增加[3H]T-2毒素透过皮肤的量并提高渗透效率。在浸浴人及猴离体皮肤真皮侧的受体液中鉴定出了[3H]T-2毒素的代谢产物。