Pan Qingqing, Zong Zhihui, Li Haibo, Xie Li, Zhu Huang, Wu Di, Liu Rong, He Bin, Pu Yuji
School of Preclinical Medicine, Chengdu University, Chengdu 610106, China.
Department of Pharmaceutical Engineering, Bengbu Medical University, Bengbu, China.
Int J Biol Macromol. 2025 Jan;284(Pt 1):137893. doi: 10.1016/j.ijbiomac.2024.137893. Epub 2024 Nov 19.
Periodontitis is a prevalent oral disease characterized by microbial infection, inflammation, and damage to periodontal tissues. Hydrogels have emerged as promising carriers and regenerative biomaterials in periodontitis therapy. This review provides a comprehensive overview of recent advances in hydrogel applications for treating periodontitis. We begin by examining the design principles of hydrogels, including their thermosensitive, self-healing, photo-crosslinkable, and adhesive properties. We then explore the innovations in drug delivery and release mechanisms within hydrogel-based systems, focusing on their roles in antibacterial, anti-inflammatory, and osteogenic therapies, as well as their synergistic combinations. By summarizing these developments, we aim to offer insights and stimulate further progress in the use of hydrogels for periodontitis and other oral health conditions.
牙周炎是一种常见的口腔疾病，其特征为微生物感染、炎症以及牙周组织损伤。水凝胶已成为牙周炎治疗中颇具前景的载体和再生生物材料。本综述全面概述了水凝胶在治疗牙周炎方面的最新进展。我们首先研究水凝胶的设计原理，包括其热敏性、自愈性、光交联性和粘附性。然后，我们探讨基于水凝胶系统的药物递送和释放机制的创新，重点关注它们在抗菌、抗炎和成骨治疗中的作用，以及它们的协同组合。通过总结这些进展，我们旨在为水凝胶在牙周炎和其他口腔健康状况中的应用提供见解并推动进一步发展。
