Wu Haoyue, Li Yuanfeng, Shi Linqi, Liu Yong, Shen Jing
Department of International VIP Dental Clinic, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, 300041, China.
Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, 300041, China.
Adv Healthc Mater. 2025 Apr;14(9):e2403206. doi: 10.1002/adhm.202403206. Epub 2025 Feb 2.
With the global population aging, awareness of oral health is rising. Periodontitis, a widespread bacterial infectious disease, is gaining attention. Current novel biomaterials address key clinical issues like bacterial infection, gum inflammation, tooth loosening, and loss, focusing on antibacterial, anti-inflammatory, and tissue regeneration properties. However, strategies that integrate the advantages of these biomaterials to achieve synergistic therapeutic effects by clearing oral biofilms, inhibiting inflammation activation, and restoring periodontal soft and hard tissue functions remain very limited. Recent studies highlight the link between periodontitis and systemic diseases, underscoring the complexity of the periodontal disease. There is an urgent need to find comprehensive treatment plans that address clinical requirements. Whether by integrating new biomaterials to enhance existing periodontal treatments or by developing novel approaches to replace traditional therapies, these efforts will drive advancements in periodontitis treatment. Therefore, this review compares novel biomaterials with traditional treatments. It highlights the design concepts and mechanisms of these functional materials, focusing on their antibacterial, anti-inflammatory, and tissue regeneration properties, and discusses the importance of developing comprehensive treatment strategies. This review aims to provide guidance for emerging periodontitis research and to promote the development of precise and efficient treatment strategies.
随着全球人口老龄化，口腔健康意识不断提高。牙周炎作为一种广泛传播的细菌性传染病，正日益受到关注。目前的新型生物材料解决了诸如细菌感染、牙龈炎症、牙齿松动和脱落等关键临床问题，重点在于抗菌、抗炎和组织再生特性。然而，通过清除口腔生物膜、抑制炎症激活以及恢复牙周软硬组织功能来整合这些生物材料的优势以实现协同治疗效果的策略仍然非常有限。最近的研究强调了牙周炎与全身性疾病之间的联系，凸显了牙周疾病的复杂性。迫切需要找到满足临床需求的综合治疗方案。无论是通过整合新的生物材料来加强现有的牙周治疗，还是通过开发新方法来取代传统疗法，这些努力都将推动牙周炎治疗的进展。因此，本综述将新型生物材料与传统治疗方法进行了比较。它突出了这些功能材料的设计理念和作用机制，重点关注其抗菌、抗炎和组织再生特性，并讨论了制定综合治疗策略的重要性。本综述旨在为新兴的牙周炎研究提供指导，并促进精准高效治疗策略的发展。
