Singer Mirko, Kanatani Sachie, Castillo Stefano Garcia, Frischknecht Friedrich, Sinnis Photini
Parasitology, Center for Infectious Diseases, Heidelberg University Medical Faculty, Heidelberg, Germany.
Johns Hopkins School of Public Health and Johns Hopkins Malaria Research Institute, 615 North Wolfe Street, Baltimore, MD, USA.
Trends Parasitol. 2024 Dec;40(12):1124-1134. doi: 10.1016/j.pt.2024.10.017. Epub 2024 Nov 20.
The circumsporozoite protein (CSP) is one of the most studied proteins of the malaria parasite. It is the target of the only licensed malaria vaccines and is essential for sporozoite formation and infectivity. Yet, the mechanisms by which CSP functions and its interactions with other proteins are only beginning to be understood. Here we review the current state of knowledge of CSP structure and function, as sporozoites develop in the mosquito and establish infection in the mammalian host, and outline outstanding questions that need to be addressed.
环子孢子蛋白（CSP）是疟原虫中研究最多的蛋白质之一。它是唯一获得许可的疟疾疫苗的靶点，对于子孢子的形成和感染性至关重要。然而，CSP发挥功能的机制及其与其他蛋白质的相互作用才刚刚开始被了解。在此，我们综述了关于CSP结构和功能的当前知识状态，包括子孢子在蚊子体内发育以及在哺乳动物宿主中建立感染的过程，并概述了需要解决的突出问题。
