Wang Weiyi, Wang Yanru, Xu Limin, Liu Xueling, Hu Yuqing, Li Junpeng, Huang Qi, Ren Shuhua, Huang Yiyun, Guan Yihui, Li Yuxin, Hua Fengchun, Ye Qing, Xie Fang
Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Department of Nuclear Medicine, Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China.
Eur J Nucl Med Mol Imaging. 2025 Mar;52(4):1510-1519. doi: 10.1007/s00259-024-06993-3. Epub 2024 Nov 22.
To investigate the relationship of synaptic loss with glucose metabolism and dopaminergic transporters in Parkinson's disease (PD) patients.
A total of 16 patients with PD and 11 age-matched healthy controls underwent positron emission tomography (PET) with the tracers [F]SynVesT-1, a ligand for the presynaptic terminal marker synaptic vesicle protein 2 A (SV2A), and FDG. PD patients also underwent PET with the dopamine transporter (DAT) ligand [18F]FP-CIT. The difference in synaptic density between PD patients and age-matched normal controls(NCs) was determined in the selected regions of interest, and the correlations of the [F]SynVesT-1 PET SUVRs with [F]FP-CIT PET SUVRs and [F]FDG PET SUVRs were evaluated.
Compared with that in the NC group, the synaptic density in the caudate region was significantly lower in the PD group (SUVR: 2.51 ± 0.36 vs. 3.18 ± 0.32, p < 0.001), especially in the pre-commissural caudate and post-commissural caudate (SUVR: 2.42 ± 0.29 vs. 2.63 ± 0.32, p < 0.01; 0.76 ± 0.31 vs. 0.97 ± 0.33, p < 0.001). A reduced synaptic density was significantly correlated with DAT (r = 0.61, p < 0.001) and glucose metabolism (r = 0.73, p < 0.001) in the post-commissural caudate. In the post-commissural regions of the caudate, there was a partial mediating effect of synaptic density on the relationship between glucose metabolism and DAT availability (indirect effect: β = 0.039, p = 0.024).
[F]SynVesT-1 binds specifically to SV2A, reflecting synaptic density, and there is a positive correlation metabolic pattern related to the changes reflected by [F]SynVesT-1 and [F]FDG.
研究帕金森病（PD）患者突触丢失与葡萄糖代谢及多巴胺能转运体之间的关系。
16例PD患者和11例年龄匹配的健康对照者接受了正电子发射断层扫描（PET），分别使用突触前末端标记物突触囊泡蛋白2A（SV2A）的配体[F]SynVesT-1和氟代脱氧葡萄糖（FDG）作为示踪剂。PD患者还接受了使用多巴胺转运体（DAT）配体[18F]FP-CIT的PET检查。在选定的感兴趣区域测定PD患者和年龄匹配的正常对照（NCs）之间的突触密度差异，并评估[F]SynVesT-1 PET标准化摄取值（SUVRs）与[F]FP-CIT PET SUVRs以及[F]FDG PET SUVRs之间的相关性。
与NC组相比，PD组尾状核区域的突触密度显著降低（SUVR：2.51±0.36 vs. 3.18±0.32，p<0.001），尤其是在连合前尾状核和连合后尾状核（SUVR：2.42±0.29 vs. 2.63±0.32，p<0.01；0.76±0.31 vs. 0.97±0.33，p<0.001）。连合后尾状核中突触密度降低与DAT（r = 0.61，p<0.001）和葡萄糖代谢（r = 0.73，p<0.001）显著相关。在尾状核的连合后区域，突触密度对葡萄糖代谢与DAT可用性之间的关系存在部分中介作用（间接效应：β = 0.039，p = 0.024）。
[F]SynVesT-1特异性结合SV2A，反映突触密度，并且存在与[F]SynVesT-1和[F]FDG所反映的变化相关的正性代谢模式。
