Dhawan Vijay, Peng Shichun, Spetsieris Phoebe G, Eidelberg David, Ma Yilong
Center for Neurosciences, Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Manhasset, New York, USA.
Department of Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
Mov Disord. 2025 Aug;40(8):1511-1527. doi: 10.1002/mds.30231. Epub 2025 May 29.
Neuroimaging with positron emission tomography (PET) has been instrumental in elucidating neurobiological mechanisms behind therapeutical trials in Parkinson's disease (PD). A variety of medical and neurosurgical interventions have been evaluated using many radioligands that reveal molecular basis for target engagement and brain responses in relation to clinical outcome measures. This review article describes major applications of metabolic brain network analysis in therapeutical studies in non-demented PD to restore functional abnormality by drug therapy, ablative lesioning, deep brain stimulation, gene therapy, and cell transplantation alongside placebo effects. The findings with brain network biomarkers using multivariate analysis are supported by regionally specific metabolic changes and clinical correlations detected by complementary univariate analysis. The review demonstrates a powerful methodology of combining multimodal neuroimaging data and network modeling approaches followed by some perspectives on future directions in this specialty area of translational research. Different neuroimaging biomarkers have been compared in light of recent advances in biofluid biomarkers. These efforts not only bring more precise understanding on mechanisms of action associated with different therapies, but also provide a road map for conducting successful clinical trials of emerging disease-modifying therapies in PD and related disorders. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
正电子发射断层扫描（PET）神经成像在阐明帕金森病（PD）治疗试验背后的神经生物学机制方面发挥了重要作用。使用多种放射性配体对各种医学和神经外科干预措施进行了评估，这些放射性配体揭示了与临床结局指标相关的靶点参与和大脑反应的分子基础。这篇综述文章描述了代谢性脑网络分析在非痴呆型PD治疗研究中的主要应用，这些研究通过药物治疗、毁损性病变、深部脑刺激、基因治疗和细胞移植以及安慰剂效应来恢复功能异常。使用多变量分析得出的脑网络生物标志物的研究结果得到了通过补充单变量分析检测到的区域特异性代谢变化和临床相关性的支持。这篇综述展示了一种将多模态神经成像数据和网络建模方法相结合的强大方法，并对这一转化研究专业领域的未来方向提出了一些观点。根据生物流体生物标志物的最新进展，对不同的神经成像生物标志物进行了比较。这些努力不仅能更精确地理解与不同疗法相关的作用机制，还为在PD及相关疾病中开展新兴疾病修饰疗法的成功临床试验提供了路线图。© 2025作者。《运动障碍》由Wiley Periodicals LLC代表国际帕金森和运动障碍协会出版。
