Ophthalmology Clinic, Department of Medicine and Science of Ageing, "G. d'Annunzio" University, Chieti-Pescara, 66100, Chieti, Italy.
Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University Chieti-Pescara, 66100, Chieti, Italy.
Sci Rep. 2024 Nov 21;14(1):28830. doi: 10.1038/s41598-024-79979-8.
This study aimed to analyze Optical Coherence Tomography (OCT) parameters and Macular Pigment Optical Density (MPOD) changes in patients affected by Retinitis pigmentosa (RP). Eighteen eyes of 18 patients suffering from early-stage RP were enrolled in our observational study. 18 eyes of 18 patients age and gender matched were enrolled as controls. Patients were analyzed at baseline by undergoing complete baseline ophthalmologic examination, Spectral-domain Optical Coherence Tomography (OCT), Electroretinogram (ERG) and Heterochromatic Flicker Photometry (HFP). Main outcome measures were Macular Pigment Optical Density (MPOD), Central macular thickness (CMT), Central Choroidal Thickness (CCT) and Choroidal Vascularity Index (CVI). Lower CCT (p = 0.006), CVI (p < 0.001) and MPOD levels (p = 0.038) were found in affected patients, whereas higher CMT was detected in cases compared to healthy controls. Correlation analysis revealed the presence of a negative correlation between BCVA and Age and CMT and BCVA and a positive correlation between CCT and MPOD and CVI and CCT. Retinal and choroidal variations occur in patients affected by early-stage RP regarding functional and anatomical changes.
本研究旨在分析色素性视网膜炎（RP）患者的光相干断层扫描（OCT）参数和黄斑色素光密度（MPOD）变化。我们的观察性研究纳入了 18 名早期 RP 患者的 18 只眼。作为对照组，我们纳入了 18 名年龄和性别匹配的患者的 18 只眼。患者在基线时接受全面的基线眼科检查、光谱域光相干断层扫描（OCT）、视网膜电图（ERG）和异色调闪烁光度法（HFP）检查。主要观察指标为黄斑色素光密度（MPOD）、中心视网膜厚度（CMT）、中心脉络膜厚度（CCT）和脉络膜血管指数（CVI）。结果发现，与健康对照组相比，受影响患者的 CCT（p=0.006）、CVI（p<0.001）和 MPOD 水平（p=0.038）较低，而 CMT 较高。相关性分析显示，BCVA 与年龄和 CMT 呈负相关，而与 CCT 呈正相关，CCT 与 MPOD 和 CVI 呈正相关。在早期 RP 患者中，视网膜和脉络膜的变化与功能和解剖变化有关。
