Toto Lisa, Ruggeri Maria Ludovica, Evangelista Federica, Trivigno Chiara, D'Aloisio Rossella, De Nicola Chiara, Viggiano Pasquale, Doronzo Emanuele, Di Nicola Marta, Porreca Annamaria, Mastropasqua Rodolfo
Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy.
Ente Ecclesiastico Ospedale Generale Regionale, "F.Miulli", Strada Provinciale Acquaviva-Santeramo Km 4100, 70021 Acquaviva delle Fonti, Italy.
J Clin Med. 2023 Feb 1;12(3):1140. doi: 10.3390/jcm12031140.
The aim of this study was to investigate optical coherence tomography (OCT) and OCT angiography (OCTA) parameters in patients with neovascular age-related macular degeneration (nAMD) and macular neovascularization (MNV) type 1, type 2, and type 3.
In this retrospective study, 105 treatment-naïve eyes of 105 patients (60 men and 45 women) with a definite diagnosis of active nAMD and MNV of different types and 105 frequency-matched age and gender healthy subjects were evaluated (61 men and 44 women). All subjects underwent a full ophthalmic examination and multimodal imaging assessment, including spectral domain (SD) OCT and OCTA. The main outcome measures were choroidal vascularity index (CVI), subfoveal choroidal thickness (SFCT), central macular thickness (CMT), and outer retina to choriocapillaris (ORCC) MNV flow area (ORCCFA).
Significant differences were found in terms of CVI, CMT, and ORCCFA between MNV 1 and the two other groups. CVI was significantly different between MNV 1 and healthy control patients ( < 0.001) and between MNV 1 and MNV 2 ( < 0.001). ORCCFA and CMT were significantly different between MNV1 and MNV2 ( < 0.005). The difference in subfoveal CT between the three groups was not statistically significant ( = 0.458). A significant negative correlation was found between CVI and ORCCFA. Furthermore, CVI showed a positive correlation with subfoveal CT.
本研究旨在调查新生血管性年龄相关性黄斑变性（nAMD）以及1型、2型和3型黄斑新生血管（MNV）患者的光学相干断层扫描（OCT）和OCT血管造影（OCTA）参数。
在这项回顾性研究中，对105例确诊为不同类型活动性nAMD和MNV的患者（60例男性和45例女性）的105只初治眼，以及105名年龄和性别匹配的健康受试者（61例男性和44例女性）进行了评估。所有受试者均接受了全面的眼科检查和多模态成像评估，包括光谱域（SD）OCT和OCTA。主要观察指标为脉络膜血管指数（CVI）、黄斑中心下脉络膜厚度（SFCT）、中心黄斑厚度（CMT）以及外层视网膜至脉络膜毛细血管（ORCC）的MNV血流面积（ORCCFA）。
MNV 1组与其他两组在CVI、CMT和ORCCFA方面存在显著差异。MNV 1组与健康对照患者之间的CVI存在显著差异（<0.001），MNV 1组与MNV 2组之间也存在显著差异（<0.001）。MNV1组与MNV2组之间的ORCCFA和CMT存在显著差异（<0.005）。三组之间黄斑中心下CT的差异无统计学意义（=0.458）。CVI与ORCCFA之间存在显著负相关。此外，CVI与黄斑中心下CT呈正相关。
