The Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA.
Invest Ophthalmol Vis Sci. 2010 Feb;51(2):1086-91. doi: 10.1167/iovs.09-3396. Epub 2009 Sep 24.
To determine whether macular pigment optical density (MPOD) is related to serum lutein or serum zeaxanthin in patients with retinitis pigmentosa.
The authors measured MPOD with heterochromatic flicker photometry, serum lutein and serum zeaxanthin by high performance liquid chromatography, and central foveal retinal thickness by optical coherence tomography (OCT) in 176 patients (age range, 18-68 years) with typical forms of retinitis pigmentosa; 37 (21%) of these patients had cystoid macular edema (CME) by OCT. The authors performed multiple regression analysis with MPOD as the dependent variable and with log(e) serum lutein and log(e) serum zeaxanthin as independent variables adjusting for age, sex, iris color, central foveal retinal thickness, and, in some analyses, serum total cholesterol.
MPOD increased with increasing serum lutein (P = 0.0017) and decreased with increasing serum total cholesterol (P = 0.0025) but was unrelated to serum zeaxanthin. MPOD was higher in patients with brown irides than in patients with lighter irides (P = 0.014) and was nonmonotonically related to central foveal retinal thickness (P < 0.0001), being lower in eyes with more photoreceptor cell loss and in eyes with moderate to marked CME.
MPOD is independently related to serum lutein, serum total cholesterol, iris color, and central foveal retinal thickness in patients with retinitis pigmentosa.
确定色素性视网膜炎患者的黄斑色素光学密度（MPOD）与血清叶黄素或血清玉米黄质是否相关。
作者使用异色调闪烁光度法测量了 176 名典型色素性视网膜炎患者的 MPOD；通过高效液相色谱法测量了血清叶黄素和血清玉米黄质；通过光学相干断层扫描（OCT）测量了中心凹视网膜厚度。其中 37 名（21%）患者通过 OCT 检测到囊样黄斑水肿（CME）。作者进行了多元回归分析，以 MPOD 为因变量，以 log（e）血清叶黄素和 log（e）血清玉米黄质为自变量，并根据年龄、性别、虹膜颜色、中心凹视网膜厚度进行了调整，在某些分析中还根据血清总胆固醇进行了调整。
MPOD 随血清叶黄素的增加而增加（P = 0.0017），随血清总胆固醇的增加而减少（P = 0.0025），但与血清玉米黄质无关。棕色虹膜患者的 MPOD 高于浅虹膜患者（P = 0.014），且与中心凹视网膜厚度呈非单调关系（P < 0.0001），在感光细胞丧失较多的眼中和中度至明显 CME 的眼中，MPOD 较低。
MPOD 与色素性视网膜炎患者的血清叶黄素、血清总胆固醇、虹膜颜色和中心凹视网膜厚度独立相关。
