Department of Health Management Medical, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan Province, China.
Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan Province, China.
Clin Epigenetics. 2024 Nov 21;16(1):165. doi: 10.1186/s13148-024-01785-w.
The pathogenesis of head and neck squamous cell carcinoma (HNSCC) is notably complex. Early symptoms are often subtle, and effective early screening methods are currently lacking. The tumors associated with HNSCC develop rapidly, exhibit high aggressiveness, and respond poorly to existing treatments, leading to low survival rates and poor prognosis. Numerous studies have demonstrated that histone posttranslational modifications (HPTMs), including acetylation, methylation, phosphorylation, and ubiquitination, play a critical role in the occurrence and progression of HNSCC. Moreover, targeting histone posttranslationally modified molecules with specific drugs has shown potential in enhancing therapeutic outcomes and improving prognosis, underscoring their significant clinical value. This review aims to summarize the role of histone posttranslational modifications in the pathogenesis and progression of HNSCC and to discuss their clinical significance, thereby providing insights into novel therapeutic approaches and drug development for this malignancy.
头颈部鳞状细胞癌（HNSCC）的发病机制显著复杂。早期症状通常较为微妙，且目前缺乏有效的早期筛查方法。与 HNSCC 相关的肿瘤发展迅速，侵袭性高，对现有治疗方法反应不佳，导致生存率低，预后差。大量研究表明，组蛋白翻译后修饰（HPTMs），包括乙酰化、甲基化、磷酸化和泛素化，在 HNSCC 的发生和进展中发挥着关键作用。此外，使用特异性药物靶向组蛋白翻译后修饰分子已显示出在增强治疗效果和改善预后方面的潜力，凸显了它们具有重要的临床价值。本综述旨在总结组蛋白翻译后修饰在 HNSCC 发病机制和进展中的作用，并探讨其临床意义，从而为这种恶性肿瘤提供新的治疗方法和药物开发思路。
