组蛋白乳酰化：喉癌研究的新前沿（综述）
Histone lactylation: A new frontier in laryngeal cancer research (Review).
作者信息
Tong Qiaoling, Huang Chunsheng, Tong Qizhen, Zhang Zhiyu
机构信息
Department of Otolaryngology, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315000, P.R. China.
Department of Anesthesiology, Ningbo Medical Center Lihuili Hospital, Medical School of Ningbo University, Ningbo, Zhejiang 315000, P.R. China.
出版信息
Oncol Lett. 2025 Jul 2;30(3):421. doi: 10.3892/ol.2025.15167. eCollection 2025 Sep.
Laryngeal cancer is a common malignant tumor of the head and neck, and its occurrence and development are closely related to epigenetic modifications. Histone lactylation, a novel form of epigenetic modification, regulates gene expression and is involved in processes such as tumor metabolic reprogramming, shaping the tumor microenvironment, maintaining tumor stem cell characteristics and developing treatment resistance. The present review highlighted the molecular mechanisms and detection methods of histone lactylation and explores its potential role in laryngeal cancer, as it may serve as a valuable biomarker for diagnosis and prognosis. Furthermore, targeting the lactylation pathway may provide novel therapeutic strategies, with the potential to improve treatment outcomes for patients. Overall, understanding the role of histone lactylation in laryngeal cancer may potentially lead to innovative diagnostic and therapeutic approaches and improve the management of laryngeal cancer in the future.
喉癌是头颈部常见的恶性肿瘤，其发生发展与表观遗传修饰密切相关。组蛋白乳酰化是一种新型的表观遗传修饰形式，可调节基因表达，并参与肿瘤代谢重编程、塑造肿瘤微环境、维持肿瘤干细胞特性和产生治疗抗性等过程。本综述重点介绍了组蛋白乳酰化的分子机制和检测方法，并探讨了其在喉癌中的潜在作用，因为它可能作为诊断和预后的有价值生物标志物。此外，靶向乳酰化途径可能提供新的治疗策略，有可能改善患者的治疗效果。总体而言，了解组蛋白乳酰化在喉癌中的作用可能会带来创新的诊断和治疗方法，并在未来改善喉癌的管理。
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