• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Do prolonged infusions of β-lactam antibiotics improve outcomes in critically ill patients with sepsis? It is time to say yes.

作者信息

Li Xiaoming, Jiang Zhengying

机构信息

Department of Critical Care Medicine, Chongqing University Cancer Hospital, 181 Han-Yu Road, Chongqing, 400030, China.

出版信息

Crit Care. 2024 Nov 21;28(1):380. doi: 10.1186/s13054-024-05139-z.

DOI:10.1186/s13054-024-05139-z
PMID:39574173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11580206/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3555/11580206/1b43be425cd0/13054_2024_5139_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3555/11580206/1b43be425cd0/13054_2024_5139_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3555/11580206/1b43be425cd0/13054_2024_5139_Fig1_HTML.jpg

相似文献

1
Do prolonged infusions of β-lactam antibiotics improve outcomes in critically ill patients with sepsis? It is time to say yes.延长β-内酰胺类抗生素输注时间能否改善重症脓毒症患者的预后？现在可以给出肯定的答案了。
Crit Care. 2024 Nov 21;28(1):380. doi: 10.1186/s13054-024-05139-z.
2
Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock: A Systematic Review and Meta-Analysis.β-内酰胺类抗生素在成人脓毒症或感染性休克中持续输注与间断输注的比较：系统评价和荟萃分析。
JAMA. 2024 Aug 27;332(8):638-648. doi: 10.1001/jama.2024.9803.
3
Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis.严重脓毒症的β-内酰胺输注（BLISS）：一项前瞻性、双中心、开放标签随机对照试验，比较了连续性与间歇性β-内酰胺输注在重症严重脓毒症患者中的应用。
Intensive Care Med. 2016 Oct;42(10):1535-1545. doi: 10.1007/s00134-015-4188-0. Epub 2016 Jan 11.
4
A protocol for a phase 3 multicentre randomised controlled trial of continuous versus intermittent β-lactam antibiotic infusion in critically ill patients with sepsis: BLING III.一项关于脓毒症重症患者连续与间歇β-内酰胺类抗生素输注的3期多中心随机对照试验方案：BLING III
Crit Care Resusc. 2019 Mar;21(1):63-68.
5
Pharmacokinetics-pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients.与危重症患者β-内酰胺类抗生素临床应用相关的药代动力学-药效学问题。
Crit Care. 2018 Sep 24;22(1):233. doi: 10.1186/s13054-018-2155-1.
6
Do Prolonged Infusions of β-Lactam Antibiotics Improve Outcomes in Critically Ill Patients With Sepsis?β-内酰胺类抗生素长时间输注能否改善脓毒症重症患者的预后？
JAMA. 2023 Jul 11;330(2):126-128. doi: 10.1001/jama.2023.6483.
7
Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis: The BLING III Randomized Clinical Trial.连续与间断β-内酰胺类抗生素输注治疗脓毒症危重症患者的比较：BLING III 随机临床试验。
JAMA. 2024 Aug 27;332(8):629-637. doi: 10.1001/jama.2024.9779.
8
Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials.严重脓毒症中连续与间断β-内酰胺输注的比较。来自随机试验的个体患者数据的荟萃分析。
Am J Respir Crit Care Med. 2016 Sep 15;194(6):681-91. doi: 10.1164/rccm.201601-0024OC.
9
A protocol for a multicentre randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients with severe sepsis: the BLING II study.一项多中心随机对照试验方案，比较连续β-内酰胺输注与重症脓毒症患者间歇性β-内酰胺给药：BLING II 研究。
Crit Care Resusc. 2013 Sep;15(3):179-85.
10
Prolonged administration of β-lactam antibiotics - a comprehensive review and critical appraisal.β-内酰胺类抗生素的长期给药——全面综述与批判性评价
Swiss Med Wkly. 2016 Oct 10;146:w14368. doi: 10.4414/smw.2016.14368. eCollection 2016.

引用本文的文献

1
Antibiotic Therapy Duration for Multidrug-Resistant Gram-Negative Bacterial Infections: An Evidence-Based Review.耐多药革兰氏阴性菌感染的抗生素治疗疗程：一项基于证据的综述。
Int J Mol Sci. 2025 Jul 18;26(14):6905. doi: 10.3390/ijms26146905.

本文引用的文献

1
Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock: A Systematic Review and Meta-Analysis.β-内酰胺类抗生素在成人脓毒症或感染性休克中持续输注与间断输注的比较：系统评价和荟萃分析。
JAMA. 2024 Aug 27;332(8):638-648. doi: 10.1001/jama.2024.9803.
2
Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis: The BLING III Randomized Clinical Trial.连续与间断β-内酰胺类抗生素输注治疗脓毒症危重症患者的比较：BLING III 随机临床试验。
JAMA. 2024 Aug 27;332(8):629-637. doi: 10.1001/jama.2024.9779.
3
Prolonged vs intermittent intravenous infusion of β-lactam antibiotics for patients with sepsis: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis.
脓毒症患者β-内酰胺类抗生素持续静脉输注与间歇静脉输注的比较：一项包含荟萃分析和试验序贯分析的随机临床试验系统评价
Ann Intensive Care. 2023 Dec 5;13(1):121. doi: 10.1186/s13613-023-01222-w.
4
International consensus recommendations for the use of prolonged-infusion beta-lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists.国际延长输注β-内酰胺类抗生素使用共识推荐：获得美国临床药学学会、英国抗菌化疗学会、囊性纤维化基金会、欧洲临床微生物学和传染病学会、美国传染病学会、重症医学学会和感染病学会药剂师学会认可。
Pharmacotherapy. 2023 Aug;43(8):740-777. doi: 10.1002/phar.2842.
5
Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial.连续性与间歇性美罗培南给药在脓毒症危重症患者中的比较：MERCY 随机临床试验。
JAMA. 2023 Jul 11;330(2):141-151. doi: 10.1001/jama.2023.10598.
6
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.拯救脓毒症运动：2021年脓毒症和脓毒性休克国际管理指南
Intensive Care Med. 2021 Nov;47(11):1181-1247. doi: 10.1007/s00134-021-06506-y. Epub 2021 Oct 2.
7
Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper.危重症成人患者的抗菌治疗药物监测：立场文件。
Intensive Care Med. 2020 Jun;46(6):1127-1153. doi: 10.1007/s00134-020-06050-1. Epub 2020 May 7.
8
Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study.全球、地区和国家脓毒症发病率和死亡率，1990-2017 年：全球疾病负担研究分析。
Lancet. 2020 Jan 18;395(10219):200-211. doi: 10.1016/S0140-6736(19)32989-7.
9
Optimization of the treatment with beta-lactam antibiotics in critically ill patients-guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique-SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d'Anesthésie et Réanimation-SFAR).β-内酰胺类抗生素在危重症患者中的治疗优化：法国药理学和治疗学学会（Société Française de Pharmacologie et Thérapeutique-SFPT）和法国麻醉与重症监护医学学会（Société Française d'Anesthésie et Réanimation-SFAR）的指南。
Crit Care. 2019 Mar 29;23(1):104. doi: 10.1186/s13054-019-2378-9.
10
Pharmacokinetics-pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients.与危重症患者β-内酰胺类抗生素临床应用相关的药代动力学-药效学问题。
Crit Care. 2018 Sep 24;22(1):233. doi: 10.1186/s13054-018-2155-1.