Salajegheh Amirali, Yahyaabadi Fatemeh Yazdi, Yazdi Farzaneh
Department of Pharmaceutical Sciences, Tehran University of Medical Sciences, Tehran.
Department of Pediatrics, Kerman University of Medical Sciences, Kerman.
Eur J Transl Myol. 2024 Nov 21;34(4):13107. doi: 10.4081/ejtm.2024.13107.
This systematic review and meta-analysis aimed to evaluate the efficacy of Low-Level Laser Therapy (LLLT) in the treatment of Rheumatoid Arthritis (RA), focusing on its effects on pain relief, grip strength, and morning stiffness. A comprehensive search was conducted across PubMed, Scopus, and Web of Science, yielding 3,111 articles. After eliminating duplicates and screening titles and abstracts, 94 full-text articles were assessed, and 23 studies met the eligibility criteria for inclusion in the systematic review. Of these, 22 studies were included in the meta-analysis. Data were extracted and analyzed using a random-effects model, with pooled Mean Differences (MD) calculated for the primary outcomes. The meta-analysis revealed that LLLT did not significantly reduce pain compared to placebo (MD = 0.00, 95% CI [-0.09, 0.09], p = 0.97). However, LLLT significantly improved grip strength (MD = -12.38, 95% CI [-17.42, -7.34], p < 0.01) and reduced morning stiffness (MD = -0.84, 95% CI [-1.33, -0.36], p < 0.01), despite substantial heterogeneity in these outcomes. LLLT shows promise in improving grip strength and reducing morning stiffness in RA patients, though it does not significantly impact pain relief. These findings highlight the potential role of LLLT as an adjunctive treatment for RA, with further research needed to optimize treatment protocols and clarify underlying mechanisms.
本系统评价和荟萃分析旨在评估低强度激光疗法（LLLT）治疗类风湿性关节炎（RA）的疗效，重点关注其对缓解疼痛、握力和晨僵的影响。我们在PubMed、Scopus和Web of Science数据库中进行了全面检索，共获得3111篇文章。在去除重复文章并筛选标题和摘要后，对94篇全文进行了评估，其中23项研究符合纳入系统评价的标准。其中，22项研究被纳入荟萃分析。使用随机效应模型提取和分析数据，并计算主要结局的合并平均差（MD）。荟萃分析显示，与安慰剂相比，LLLT在减轻疼痛方面无显著差异（MD = 0.00，95% CI [-0.09, 0.09]，p = 0.97）。然而，尽管这些结局存在显著异质性，但LLLT显著提高了握力（MD = -12.38，95% CI [-17.42, -7.34]，p < 0.01）并减轻了晨僵（MD = -0.84，95% CI [-1.33, -0.36]，p < 0.01）。LLLT在改善RA患者握力和减轻晨僵方面显示出前景，尽管它对缓解疼痛没有显著影响。这些发现凸显了LLLT作为RA辅助治疗的潜在作用，需要进一步研究以优化治疗方案并阐明潜在机制。
