Sánchez María B, Callaghan Michael J, Selfe James, Twigg Michael, Smith Toby
Dept of Health Professions, Manchester Metropolitan University, Manchester, M15 6GX, UK.
School of Pharmacy, University of East Anglia, Norwich, NR4 7TQ, UK.
Pain Manag. 2024 Oct-Nov;14(10-11):557-569. doi: 10.1080/17581869.2024.2421153. Epub 2024 Nov 22.
To determine the efficacy of transdermal anti-inflammatory patches in the treatment of acute and chronic musculoskeletal pain. A comprehensive search of: Cochrane Central register of controlled trials, EMBASE, MEDLINE, CINAHL and PubMed, for studies using transdermal anti-inflammatory patches vs placebo for management of musculoskeletal pain, e.g. soft tissue injuries or tendonitis (last search January 2024). Cochrane Risk of Bias Tools v1 was used for quality assessment and GRADE determined certainty of evidence. Meta-analysis was performed. Twenty-three randomized placebo-controlled trials (n = 4729) were included. There was low-certainty evidence that transdermal patches provided statistically and clinically significant pain relief on movement at long-term follow-up for chronic musculoskeletal pain (effect size -2-69 (95% CI: -4.14, -1.24) and at short-term follow-up which was non-clinically significant, (-1.24: 95% CI: -1.78, -0.69). Several types of transdermal anti-inflammatory patches may offer short-term and long-term pain relief for acute and chronic musculoskeletal conditions. However, the clinical significance of this effect for the long-term pain relief was based on low-certainty evidence of transdermal anti-inflammatory patches versus placebo; for short-term pain there was an overall non-clinically significant improvement. Performing a meta-analysis for all outcomes was not possible due to insufficiency in the evidence-base. www.crd.york.ac.uk/prospero identifier is CRD42020185944.
为确定透皮抗炎贴剂治疗急慢性肌肉骨骼疼痛的疗效。全面检索了Cochrane对照试验中央登记库、EMBASE、MEDLINE、CINAHL和PubMed，以查找使用透皮抗炎贴剂与安慰剂治疗肌肉骨骼疼痛（如软组织损伤或肌腱炎）的研究（最后一次检索时间为2024年1月）。使用Cochrane偏倚风险工具v1进行质量评估，并采用GRADE确定证据的确定性。进行了荟萃分析。纳入了23项随机安慰剂对照试验（n = 4729）。有低确定性证据表明，对于慢性肌肉骨骼疼痛，透皮贴剂在长期随访时可在统计学和临床上显著缓解运动时的疼痛（效应量-2.69（95%CI：-4.14，-1.24）），而在短期随访时虽有缓解但无临床意义（-1.24：95%CI：-1.78，-0.69）。几种类型的透皮抗炎贴剂可能为急慢性肌肉骨骼疾病提供短期和长期的疼痛缓解。然而，这种长期疼痛缓解效果的临床意义基于透皮抗炎贴剂与安慰剂对比的低确定性证据；对于短期疼痛，总体上无临床显著改善。由于证据基础不足，无法对所有结局进行荟萃分析。www.crd.york.ac.uk/prospero标识符为CRD42020185944。
