Woitowitz H J, Lange H J, Beierl L, Rathgeb M, Schmidt K, Ulm K, Giesen T, Woitowitz R H, Pache L, Rödelsperger K
Int Arch Occup Environ Health. 1986;57(3):161-71. doi: 10.1007/BF00405785.
In 1972, a procedure was introduced by the Industrial Injuries Insurance Institutes (Berufsgenossenschaften) of the Federal Republic of Germany, which is to be used by the special occupational health service for employees exposed to asbestos dust. Since 1 January 1972, occupational health examinations are performed when exposure to asbestos dust has been of at least 3 years' duration. On 1 January 1977, a prospective cohort study was started with employees formerly exposed to asbestos dust whilst working for companies manufacturing or using asbestos. Data on these persons are collected in the Central Register of Employees Exposed to Asbestos Dust of the Industrial Injuries Insurance Institutes. A total of 3,070 male and female employees in whom asbestos exposure terminated after 1 January 1972 formed subcohort I of the study. For comparison, 665 persons whose exposure terminated before 1 January 1972 served as subcohort II. In addition to several other inclusion criteria, each individual's permission was required before personal data could be evaluated. Of the subjects in the two subcohorts, 185 and 71, respectively, had died by 31 December 1982. Tumours were more frequently than this cause of death is expected in the general population. In addition to a high incidence of mesothelioma, the standard mortality rate was especially increased for lung cancer. The proportional mortality rates of about 40% for tumours of all sites (with about 17% lung cancer and 8% mesothelioma) especially in subcohort II, seemed to be comparable to the international figures for epidemiological mortality.
1972年，德意志联邦共和国的工业伤害保险协会（同业公会）引入了一种程序，供特殊职业健康服务机构用于接触石棉粉尘的员工。自1972年1月1日起，当接触石棉粉尘的时间至少达到3年时，进行职业健康检查。1977年1月1日，对曾在制造或使用石棉的公司工作时接触过石棉粉尘的员工启动了一项前瞻性队列研究。这些人的数据收集在工业伤害保险协会的石棉粉尘接触员工中央登记册中。共有3070名男女员工，其石棉接触在1972年1月1日之后终止，构成了该研究的第一亚组。作为对照，665名接触在1972年1月1日之前终止的人员作为第二亚组。除了其他几项纳入标准外，在评估个人数据之前需要获得每个人的许可。到1982年12月31日，两个亚组中的受试者分别有185人和71人死亡。肿瘤导致死亡的频率高于一般人群的预期。除间皮瘤发病率高外，肺癌的标准死亡率尤其升高。所有部位肿瘤的比例死亡率约为40%（其中肺癌约为17%，间皮瘤约为8%），特别是在第二亚组中，似乎与国际流行病学死亡率数据相当。
