Yang Xiaosi, Duan Shuqiang, Zha Jie, Jiang Tao, Ye Chun, Yu Shuihong
School of Basic Medicine, Anqing Medical College, Anqing City, Anhui Province, PR China.
Department of Pathology, Anqing Municipal Hospital, Anqing City, Anhui Province, PR China.
Histol Histopathol. 2024 Nov 12:18847. doi: 10.14670/HH-18-847.
This study aims to detect the expression of phosphorylated PERK in breast cancer using immunohistochemistry and explore its significance. We examined 134 cases of formalin-fixed and paraffin-embedded breast cancer tissues. It was found that the expression of phosphorylated PERK in ductal carcinoma was higher than that in lobular carcinoma, and the difference between them was statistically significant, suggesting that phosphorylated PERK played different roles in the occurrence and development of different types of breast cancer. Compared with Ki-67-negative breast cancer tissues, phosphorylated PERK has higher expression in Ki-67-positive tissues and is positively correlated with Ki67 expression, indicating that phosphorylated PERK plays an important role in breast cancer's malignant proliferation and progression. We also found a positive correlation between phosphorylated PERK expression and the histological grading of invasive ductal carcinoma, indicating that phosphorylated PERK plays an important role in the differentiation of invasive ductal carcinoma. Our study revealed the differential expression of phosphorylated PERK in subtypes of breast cancer. It contributed to the malignant proliferation of breast cancer and tissue differentiation of invasive ductal carcinoma of the breast.
本研究旨在采用免疫组织化学方法检测乳腺癌中磷酸化PERK的表达并探讨其意义。我们检测了134例福尔马林固定石蜡包埋的乳腺癌组织。发现导管癌中磷酸化PERK的表达高于小叶癌，两者差异具有统计学意义，提示磷酸化PERK在不同类型乳腺癌的发生发展中发挥不同作用。与Ki-67阴性的乳腺癌组织相比，磷酸化PERK在Ki-67阳性组织中表达更高，且与Ki67表达呈正相关，表明磷酸化PERK在乳腺癌的恶性增殖和进展中起重要作用。我们还发现磷酸化PERK表达与浸润性导管癌的组织学分级呈正相关，提示磷酸化PERK在浸润性导管癌的分化中起重要作用。我们的研究揭示了磷酸化PERK在乳腺癌亚型中的差异表达。它促进了乳腺癌的恶性增殖以及乳腺浸润性导管癌的组织分化。
