Ilie Ionuţ-Octavian, Mărgăritescu Otilia Clara, Stepan Alex Emilian, Ciurea Raluca Niculina, Florescu Mirela Marinela, Munteanu Cristina, Şerbănescu Mircea Sebastian, Mărgăritescu Claudiu
PhD student, Department of Morphopathology, University of Medicine and Pharmacy of Craiova, Romania.
Department of Neurosurgery, University of Medicine and Pharmacy of Craiova, Romania.
Curr Health Sci J. 2024 Jul-Sep;50(3):411-420. doi: 10.12865/CHSJ.50.03.08. Epub 2024 Sep 30.
Oral Squamous Cell Carcinoma (OSCC) it was reported to be the 6th on the list of human malignant neoplasms responsible for high morbidity and mortality worldwide. We conducted a retrospective study between 2009-2019, investigating 50 such cancers hospitalized and diagnosed during this period in our institution. The purpose of the study was to establish a clinical-morphological profile of this type of cancer developed in the geographical area served by our institution. The epidemiological study highlighted the predominance of cases in men over 50 years old, mainly affecting the tongue, followed by the lips and oral floor. The histopathological study showed the prevalence of conventional cases of OSCC (70%) and the rest of the cases belonging to rarer forms (acantholytic-18%, verrucous-6%, basaloid-4% and sarcomatoid-2%). In terms of the degree of differentiation, the moderately differentiated cases prevailed (64%) and according to the TNM clinical stage, most cases were diagnosed in stage II (36%) and IV (26%). 70% of investigated cases presented muscle invasion and 38% perineural invasion. Our investigation highlighted the existence of particular morpho-clinical profiles depending on the tumor topography. Thus, tumors developed at the tongue level reached the maximum frequency in the 6th decade of life, being absent in the 8th decade and most often associated muscle invasion and perineural invasion, being diagnosed in advanced pTNM stages.
据报道，口腔鳞状细胞癌（OSCC）是全球范围内导致高发病率和高死亡率的人类恶性肿瘤中的第六位。我们进行了一项回顾性研究，研究对象为2009年至2019年期间在我们机构住院并确诊的50例此类癌症患者。该研究的目的是建立在我们机构服务的地理区域内发生的这种类型癌症的临床形态学特征。流行病学研究强调，50岁以上男性病例占主导地位，主要影响舌头，其次是嘴唇和口腔底部。组织病理学研究显示，常规OSCC病例占多数（70%），其余病例属于罕见类型（棘层松解型占18%，疣状型占6%，基底样型占4%，肉瘤样型占2%）。在分化程度方面，中度分化病例占主导（64%），根据TNM临床分期，大多数病例在II期（36%）和IV期（26%）被诊断出来。70%的研究病例出现肌肉浸润，38%出现神经周围浸润。我们的调查强调，根据肿瘤部位存在特定的形态临床特征。因此，发生在舌头部位的肿瘤在生命的第六个十年达到最高发病率，在第八个十年不存在，并且最常伴有肌肉浸润和神经周围浸润，在晚期pTNM分期被诊断出来。
