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超越表象:高甘油三酯血症性胰腺炎中缺失的环节

Beyond the Obvious: The Missing Pieces in Hypertriglyceridemia-Induced Pancreatitis.

作者信息

Zaman Muhammad A, Milton Karly, Jilani Mina

机构信息

Internal Medicine, Conemaugh Memorial Medical Center, Johnstown, USA.

Emergency Medicine, Lake Erie College of Osteopathic Medicine, Pittsburg, USA.

出版信息

Cureus. 2024 Oct 22;16(10):e72140. doi: 10.7759/cureus.72140. eCollection 2024 Oct.

DOI:10.7759/cureus.72140
PMID:39574983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11581138/
Abstract

The incidence of acute pancreatitis in the United States has been increasing for the last few years and hypertriglyceridemia is a common cause of acute pancreatitis. In this case report, we present an interesting case of a young patient with hypertriglyceridemia-induced acute pancreatitis. The patient had multiple causes for increased blood triglyceride levels, including recently started icosapent ethyl, metabolic syndrome, and possible familial chylomicronemia syndrome.

摘要

在过去几年中,美国急性胰腺炎的发病率一直在上升,高甘油三酯血症是急性胰腺炎的常见病因。在本病例报告中,我们介绍了一例有趣的年轻患者,其患有高甘油三酯血症诱发的急性胰腺炎。该患者血液甘油三酯水平升高有多种原因,包括最近开始服用二十碳五烯酸乙酯、代谢综合征以及可能的家族性乳糜微粒血症综合征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e849/11581138/b51533967bef/cureus-0016-00000072140-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e849/11581138/77a743ff3840/cureus-0016-00000072140-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e849/11581138/f4cf715d1db6/cureus-0016-00000072140-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e849/11581138/b51533967bef/cureus-0016-00000072140-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e849/11581138/77a743ff3840/cureus-0016-00000072140-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e849/11581138/f4cf715d1db6/cureus-0016-00000072140-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e849/11581138/b51533967bef/cureus-0016-00000072140-i03.jpg

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本文引用的文献

1
Validation of the familial chylomicronaemia syndrome (FCS) score in an ethnically diverse cohort from UK FCS registry: Implications for diagnosis and differentiation from multifactorial chylomicronaemia syndrome (MCS).验证家族性乳糜微粒血症综合征(FCS)评分在英国 FCS 注册中心的多种族队列中的有效性:对诊断和与多因素乳糜微粒血症综合征(MCS)的鉴别诊断的影响。
Atherosclerosis. 2024 Apr;391:117476. doi: 10.1016/j.atherosclerosis.2024.117476. Epub 2024 Feb 10.
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Acute pancreatitis and metabolic syndrome: genetic correlations and causal associations.急性胰腺炎与代谢综合征:遗传相关性和因果关联。
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Real-world safety of icosapent ethyl: analysis based on spontaneous reports in FAERS database.
依泽替米贝的真实世界安全性:基于 FAERS 数据库自发报告的分析。
Expert Opin Drug Saf. 2024 Mar;23(3):373-383. doi: 10.1080/14740338.2023.2274946. Epub 2023 Oct 27.
4
Efficacy and safety of lomitapide in familial chylomicronaemia syndrome.洛美他派治疗家族性乳糜微粒血症综合征的疗效与安全性。
Atherosclerosis. 2022 Oct;359:13-19. doi: 10.1016/j.atherosclerosis.2022.08.017. Epub 2022 Sep 10.
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Acute pancreatitis secondary to tamoxifen-associated hypertriglyceridemia: A clinical update.他莫昔芬相关高甘油三酯血症继发急性胰腺炎:临床进展
J Oncol Pharm Pract. 2023 Jan;29(1):218-225. doi: 10.1177/10781552221093969. Epub 2022 Apr 12.
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Causes, clinical findings and therapeutic options in chylomicronemia syndrome, a special form of hypertriglyceridemia.乳糜微粒血症综合征(一种特殊类型的高甘油三酯血症)的病因、临床特征和治疗选择。
Lipids Health Dis. 2022 Feb 10;21(1):21. doi: 10.1186/s12944-022-01631-z.
7
Acute pancreatitis secondary to cocaine use: a case-based systematic literature review.基于病例的系统性文献回顾:可卡因使用导致的急性胰腺炎。
Clin J Gastroenterol. 2021 Aug;14(4):1269-1277. doi: 10.1007/s12328-021-01427-1. Epub 2021 May 4.
8
Metabolic syndrome components and acute pancreatitis: a case-control study in China.代谢综合征组分与急性胰腺炎:一项中国的病例对照研究
BMC Gastroenterol. 2021 Jan 6;21(1):17. doi: 10.1186/s12876-020-01579-3.
9
Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome.伏拉瑞斯森与家族性乳糜微粒血症综合征中的甘油三酯水平
N Engl J Med. 2019 Aug 8;381(6):531-542. doi: 10.1056/NEJMoa1715944.
10
Identification and diagnosis of patients with familial chylomicronaemia syndrome (FCS): Expert panel recommendations and proposal of an "FCS score".家族性乳糜微粒血症综合征(FCS)患者的识别和诊断:专家小组建议和“FCS 评分”提案。
Atherosclerosis. 2018 Aug;275:265-272. doi: 10.1016/j.atherosclerosis.2018.06.814. Epub 2018 Jun 18.