Shen Zhemin, Wang Xueqiao, Zhen Zili, Wang Yao, Sun Peilong
Department of General Surgery, Jinshan Hospital, Fudan University, Shanghai, China.
Department of Otorhinolaryngology Head and Neck Surgery, Jinshan Hospital, Fudan University, Shanghai, China.
BMC Gastroenterol. 2021 Jan 6;21(1):17. doi: 10.1186/s12876-020-01579-3.
Acute pancreatitis (AP) is a common inflammatory disorder of the pancreas. Recent evidence has shown that metabolic syndrome is positively correlated with the severity of AP. However, only a few studies have revealed the relationship between metabolic syndrome and the occurrence of AP. We therefore elucidated the association between metabolic syndrome and the occurrence of AP.
A hospital-based case-control study was conducted. A total of 705 patients admitted to our hospital from January 2016 to December 2018 were included in the study. Subjects were divided into case and control groups according to their diagnosis: (1) According to the revised Atlanta classification from 2012, patients diagnosed with AP were enrolled in the case group. (2) Patients without a history of AP or any disease related to metabolic syndrome were allocated into the control group. Controls were matched to cases individually by sex and age (control/case ratio = 1).
The incidence rate of metabolic syndrome in AP patients was 30.9%, which was more frequent than that in controls (13.2%) (OR 2.837; 95% CI 1.873-4.298, p < 0.001). In the multivariate regression analysis, a history of smoking or alcohol consumption and biliary stones were significantly associated with AP (OR 2.441; 95% CI 1.865-5.172, p < 0.001; OR 1.777; 95% CI 1.060-2.977, p = 0.029; OR 28.995; 95% CI 13.253-63.435, p < 0.001). In addition, the occurrence of AP was significantly associated with total cholesterol (TC) (OR 1.992; 95% CI 1.246-3.183, p = 0.004), triglyceride (TG) (OR 2.134; 95% CI 1.403-3.245, p < 0.001), hyperglycaemia (OR 2.261; 95% CI 1.367-3.742, p = 0.001), and apolipoprotein A (Apo A) (OR 0.270; 95% CI 0.163-0.447, p < 0.001).
Metabolic syndrome and its components were associated with AP occurrence.
急性胰腺炎（AP）是胰腺常见的炎症性疾病。最近的证据表明，代谢综合征与AP的严重程度呈正相关。然而，只有少数研究揭示了代谢综合征与AP发生之间的关系。因此，我们阐明了代谢综合征与AP发生之间的关联。
进行了一项基于医院的病例对照研究。纳入了2016年1月至2018年12月在我院住院的705例患者。根据诊断将受试者分为病例组和对照组：（1）根据2012年修订的亚特兰大分类，诊断为AP的患者纳入病例组。（2）无AP病史或任何与代谢综合征相关疾病的患者被分配到对照组。对照组按性别和年龄与病例组个体匹配（对照/病例比 = 1）。
AP患者中代谢综合征的发生率为30.9%，高于对照组（13.2%）（OR 2.837；95%CI 1.873 - 4.298，p < 0.001）。在多因素回归分析中，吸烟或饮酒史以及胆结石与AP显著相关（OR 2.441；95%CI 1.865 - 5.172，p < 0.001；OR 1.777；95%CI 1.060 - 2.977，p = 0.029；OR 28.995；95%CI 13.253 - 63.435，p < 0.001）。此外，AP的发生与总胆固醇（TC）（OR 1.992；95%CI 1.246 - 3.183，p = 0.004）、甘油三酯（TG）（OR 2.134；95%CI 1.403 - 3.245，p < 0.001）、高血糖（OR 2.261；95%CI 1.367 - 3.742，p = 0.001）和载脂蛋白A（Apo A）（OR 0.270；95%CI 0.163 - 0.447，p < 0.001）显著相关。
代谢综合征及其组分与AP的发生有关。
