Diab Sdrah, Al-Janabi Moatasem Hussein, Diab Ibrahim, Hassan Fouz
Department of Dermatology and sexually transmitted disease, Tishreen University Hospital, Lattakia, Syria.
Department of Pathology, Cancer Research Center, Tishreen University Hospital, Lattakia, Syria.
Oxf Med Case Reports. 2024 Nov 20;2024(11):omae138. doi: 10.1093/omcr/omae138. eCollection 2024 Nov.
Rupioid psoriasis is a rare subtype of psoriasis characterized by distinctive lesions resembling oyster shells, known as rupioid lesions. This subtype is particularly uncommon in the pediatric population and is often associated with poor treatment compliance. Ustekinumab, an IgG monoclonal antibody, targets IL-12 and IL-23, reducing the release of proinflammatory cytokines TNFα, IL-2, and IL-17α, which play vital roles in psoriasis pathophysiology. Approved for pediatric patients aged six years and older, ustekinumab provides a therapeutic option for moderate to severe psoriasis. We present the case of a 10-year-old girl diagnosed with psoriasis vulgaris at age two. She presented with rupioid lesions following a urinary tract infection that had been treated with oral cefixime (200 mg). After conducting appropriate tests, ustekinumab (45 mg subcutaneously) was administered, leading to significant improvements in the thickness of the lesions and overall appearance. This case demonstrates ustekinumab's efficacy in treating this challenging form of psoriasis.
蛎壳状银屑病是银屑病的一种罕见亚型，其特征为具有独特的类似牡蛎壳的皮损，即蛎壳状皮损。这种亚型在儿科人群中尤为罕见，且常与治疗依从性差有关。乌司奴单抗是一种IgG单克隆抗体，靶向IL-12和IL-23，减少促炎细胞因子TNFα、IL-2和IL-17α的释放，这些细胞因子在银屑病病理生理学中起重要作用。乌司奴单抗已被批准用于6岁及以上的儿科患者，为中度至重度银屑病提供了一种治疗选择。我们报告一例10岁女孩的病例，她在2岁时被诊断为寻常型银屑病。在接受口服头孢克肟（200毫克）治疗的尿路感染后，她出现了蛎壳状皮损。在进行适当检查后，给予乌司奴单抗（皮下注射45毫克），皮损厚度和整体外观有显著改善。该病例证明了乌司奴单抗在治疗这种具有挑战性的银屑病形式方面的疗效。
