Paediatrics, Wuhan Xinzhou District People's Hospital, 430400 Wuhan, Hubei, China.
Gynaecology and Obstetrics, Wuhan Xinzhou District People's Hospital, 430400 Wuhan, Hubei, China.
Arch Esp Urol. 2023 Jul;76(5):313-318. doi: 10.56434/j.arch.esp.urol.20237605.36.
This study aims to explore the effects of cefixime on immune functions and inflammatory factors in children with urinary tract infection and to investigate its nursing strategies.
A total of 161 children with urinary tract infection who were diagnosed in our hospital from November 2019 to November 2021 were selected. All children were treated with cefixime and received targeted nursing strategies. The indices of immune functions and the levels of inflammatory factors were compared before and after the treatment. The satisfaction degree of children's family members, recurrence rate and incidence of adverse reactions were measured.
The levels of CD3, CD4 and CD4/CD8 in children after the treatment were significantly higher but the CD8 level was significantly lower than those before the treatment ( < 0.001). The levels of C-reactive protein, tumour necrosis factor-α and interleukin-6 after the treatment were lower than those before the treatment ( < 0.001). The average score of nursing satisfaction of children's family members was (84.53 ± 13.65) points, with the total satisfaction degree of 90.68% (146/161). Within 6 months after the treatment, only six children had urinary tract infection again and the recurrence rate was 3.73% (6/161). During the treatment, seven children had adverse reactions to the drug, with an incidence rate of 4.35% (7/161).
Cefixime can improve the immune function of children with urinary tract infection and reduce the levels of inflammatory factors. The implementation of targeted nursing strategies can improve clinical satisfaction and reduce the recurrence rate of the disease and thus can be helpful to establish a comprehensive and efficient clinical program for children with urinary tract infection.
本研究旨在探讨头孢克肟对尿路感染患儿免疫功能和炎症因子的影响，并探讨其护理策略。
选取我院 2019 年 11 月至 2021 年 11 月收治的 161 例尿路感染患儿，均采用头孢克肟治疗，并给予针对性护理策略。比较治疗前后免疫功能指标和炎症因子水平，测量患儿家属满意度、复发率和不良反应发生率。
治疗后患儿 CD3、CD4 和 CD4/CD8 水平明显升高，而 CD8 水平明显降低，与治疗前比较差异有统计学意义（<0.001）。治疗后 C 反应蛋白、肿瘤坏死因子-α和白细胞介素-6 水平低于治疗前，差异有统计学意义（<0.001）。患儿家属护理满意度平均得分为（84.53±13.65）分，总满意度为 90.68%（146/161）。治疗后 6 个月内，仅 6 例患儿再次发生尿路感染，复发率为 3.73%（6/161）。治疗期间，7 例患儿出现药物不良反应，发生率为 4.35%（7/161）。
头孢克肟可改善尿路感染患儿的免疫功能，降低炎症因子水平。实施针对性护理策略可提高临床满意度，降低疾病复发率，有助于建立尿路感染患儿的综合高效临床方案。
