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银屑病伴发间质性肺疾病

Concomitant Interstitial Lung Disease With Psoriasis.

作者信息

Kharibam Prabin, Laishram Sushma, Choudhary Nikita, Choudhury Arnab, Kant Ravi

机构信息

Department of Internal Medicine, All India Institute of Medical Sciences Rishikesh, Rishikesh, IND.

Department of Dermatology, Venereology, and Leprosy, All India Institute of Medical Sciences Rishikesh, Rishikesh, IND.

出版信息

Cureus. 2022 Jul 18;14(7):e26979. doi: 10.7759/cureus.26979. eCollection 2022 Jul.

DOI:10.7759/cureus.26979
PMID:35989802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9385169/
Abstract

Interstitial lung disease is occasionally reported in patients with psoriasis as drug-induced pneumonitis secondary to concomitant use of immunosuppressants in most cases. Although few cases have been reported describing the simultaneous existence of psoriasis and interstitial pneumonia, there are no reports that clearly show their direct association. A 55-year-old male known case of psoriasis and hypertension presented to the emergency department with complaints of pain and weakness of bilateral upper limbs following an episode of seizure and shortness of breath on exertion for one year. Following workup, the patient was diagnosed to have interstitial lung disease. There was no history of any immunosuppressant or use of biologics. So, immune dysfunction triggered by psoriasis might have caused the lung fibrotic changes. Careful monitoring of lung and skin lesions is vital for diagnosing psoriasis-associated pneumonia.

摘要

在大多数情况下,银屑病患者偶尔会报告出现间质性肺病,这是继发于同时使用免疫抑制剂的药物性肺炎。虽然有少数病例报告描述了银屑病和间质性肺炎同时存在,但尚无报告明确显示它们之间的直接关联。一名55岁男性,已知患有银屑病和高血压,因癫痫发作后双侧上肢疼痛和无力以及一年来劳力性呼吸急促而到急诊科就诊。经过检查,该患者被诊断为间质性肺病。没有任何免疫抑制剂或生物制剂使用史。因此,银屑病引发的免疫功能障碍可能导致了肺部纤维化改变。仔细监测肺部和皮肤病变对于诊断银屑病相关肺炎至关重要。

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本文引用的文献

1
The risk of interstitial lung disease during biological treatment in Japanese patients with psoriasis.日本银屑病患者生物治疗期间发生间质性肺病的风险。
Clin Exp Dermatol. 2020 Oct;45(7):853-858. doi: 10.1111/ced.14259. Epub 2020 Jun 29.
2
Concomitant Interstitial Lung Disease with Psoriasis.银屑病合并间质性肺疾病
Can Respir J. 2019 Aug 25;2019:5919304. doi: 10.1155/2019/5919304. eCollection 2019.
3
Interstitial Pneumonia in Psoriasis.银屑病中的间质性肺炎
银屑病可能增加特发性肺纤维化的风险:一项两样本孟德尔随机化研究。
Respir Res. 2024 Feb 26;25(1):101. doi: 10.1186/s12931-024-02721-5.
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CT Patterns of Interstitial Lung Disease in Patients with Plaque Psoriasis: A Retrospective Case Series Study.斑块状银屑病患者间质性肺病的 CT 表现:一项回顾性病例系列研究。
Medicina (Kaunas). 2023 Sep 12;59(9):1650. doi: 10.3390/medicina59091650.
Mayo Clin Proc Innov Qual Outcomes. 2018 Sep 20;2(4):370-377. doi: 10.1016/j.mayocpiqo.2018.07.006. eCollection 2018 Dec.