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INTRODUCTION

Primary liver cancer (PLC) occupied the 6th and 3rd place in the world respectively in terms of incidence and mortality in 2020. The objective of this work was to study the survival and prognostic factors of primary liver cancer from 2014 to 2020 in Cotonou.

MATERIALS AND METHODS

This retrospective cohort study included 150 patients registered with primary liver cancer, in the database of the Cotonou Cancer Registry, over a seven-years period from 01/01/2014 to 12/31/2020. R 3. 6. 1 software was used for data analysis. The Kaplan-Meier method was used to estimate patient survival. The comparison of the survival curves was made by the Log-Rank test. The Cox proportional hazard model was established to identify predictors of mortality. The statistical significance threshold was set at 5%.

RESULTS

The mean age of the subjects was 51. 7 ± 14. 9 years and the sex-ratio 2. 7. Half of the deaths occurred within the first 2 months after diagnosis. The prognostic factors, after multivariate analysis, were: age ≥ 60 (Hazard Ratio adjusted, HRa = 1. 7; IC 95% [1. 10-2. 51]), alcohol consumption (HRa = 3. 7; [1. 33-9. 42]), therapeutic itinerary (HRa = 1. 9; [1. 24-3. 02]), hepatitis B virus infection (HRa = 7. 7; [3. 26-12. 29]), hepatitis C virus infection (HRa = 3. 6; [1. 38-9. 43]) and time to consultation ≥4 weeks (HRa = 2. 0; [1. 01-4. 05]).

CONCLUSION

The mortality of patients with CPF in Cotonou is high with a median survival of 2 months. Factors, mostly modifiable, are associated with this mortality.