Chai Ruiming, Bian Wen-Jie
Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
School of Life Sciences, Westlake University, Hangzhou, China.
Front Neurosci. 2024 Nov 7;18:1479420. doi: 10.3389/fnins.2024.1479420. eCollection 2024.
Adolescence is a pivotal stage during development when one's personality, emotion, and behavioral traits are shaped to a great extent, and the underlying neural circuits undergo substantial developmental organizations. Dramatic and dynamic changes occur in sleep architecture throughout the postnatal developmental course. Insufficient sleep and disruption of sleep/wake coherence are prevalent among the adolescents worldwide, and even so in young patients with neuropsychiatric conditions. Although accumulating evidence has suggested a tight association between sleep disruption and depression/anxiety, the causal relationship remains largely unclear. More importantly, most of these studies focused on adult subjects, and little is known about the role of sleep during the development of mood and behavior. Here we review recent studies investigating the acute and chronic effects of adolescent sleep disruption on depression and anxiety both in humans and rodent models with focuses on the assessment methodology and age. By discussing the findings and unsolved problems, we hope to achieve a better understanding of the relationship between sleep and mental health in adolescents and provide insights for future research.
青春期是发育过程中的一个关键阶段，在此期间，一个人的个性、情感和行为特征在很大程度上得以塑造，其潜在的神经回路也经历大量的发育组织过程。在整个出生后的发育过程中，睡眠结构会发生剧烈而动态的变化。全球范围内，青少年中睡眠不足以及睡眠/觉醒连贯性被打乱的情况普遍存在，患有神经精神疾病的年轻患者中亦是如此。尽管越来越多的证据表明睡眠紊乱与抑郁/焦虑之间存在紧密联系，但因果关系在很大程度上仍不明确。更重要的是，这些研究大多聚焦于成年受试者，而对于睡眠在情绪和行为发展过程中的作用知之甚少。在此，我们回顾近期关于青少年睡眠紊乱对人类和啮齿动物模型中抑郁和焦虑的急性及慢性影响的研究，重点关注评估方法和年龄。通过讨论研究结果及未解决的问题，我们希望能更好地理解青少年睡眠与心理健康之间的关系，并为未来研究提供见解。
