Key Laboratory of Brain-Machine Intelligence for Information Behavior (Ministry of Education and Shanghai), School of Business and Management, Shanghai International Studies University, Shanghai 201620, China.
Center for Functional Neuroimaging and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Proc Natl Acad Sci U S A. 2023 Jun 27;120(26):e2214505120. doi: 10.1073/pnas.2214505120. Epub 2023 Jun 20.
Sleep loss robustly disrupts mood and emotion regulation in healthy individuals but can have a transient antidepressant effect in a subset of patients with depression. The neural mechanisms underlying this paradoxical effect remain unclear. Previous studies suggest that the amygdala and dorsal nexus (DN) play key roles in depressive mood regulation. Here, we used functional MRI to examine associations between amygdala- and DN-related resting-state connectivity alterations and mood changes after one night of total sleep deprivation (TSD) in both healthy adults and patients with major depressive disorder using strictly controlled in-laboratory studies. Behavioral data showed that TSD increased negative mood in healthy participants but reduced depressive symptoms in 43% of patients. Imaging data showed that TSD enhanced both amygdala- and DN-related connectivity in healthy participants. Moreover, enhanced amygdala connectivity to the anterior cingulate cortex (ACC) after TSD associated with better mood in healthy participants and antidepressant effects in depressed patients. These findings support the key role of the amygdala-cingulate circuit in mood regulation in both healthy and depressed populations and suggest that rapid antidepressant treatment may target the enhancement of amygdala-ACC connectivity.
睡眠缺失会严重扰乱健康个体的情绪和情绪调节能力，但在一部分抑郁症患者中可能会产生短暂的抗抑郁作用。这种矛盾作用的神经机制尚不清楚。先前的研究表明，杏仁核和背侧神经节（DN）在抑郁情绪调节中起着关键作用。在这里，我们使用功能磁共振成像（fMRI），在严格控制的实验室研究中，检查了健康成年人和重度抑郁症患者在一夜完全睡眠剥夺（TSD）后，杏仁核和 DN 相关静息状态连接改变与情绪变化之间的关联。行为数据表明，TSD 增加了健康参与者的负面情绪，但减少了 43%患者的抑郁症状。成像数据显示，TSD 增强了健康参与者的杏仁核和 DN 相关连接。此外，TSD 后杏仁核对前扣带皮层（ACC）的连接增强与健康参与者的情绪改善以及抑郁患者的抗抑郁作用相关。这些发现支持了杏仁核-扣带回路在健康和抑郁人群中情绪调节中的关键作用，并表明快速抗抑郁治疗可能针对增强杏仁核-ACC 连接。
