Zattoni J
Minerva Anestesiol. 1980 Feb;46(2):189-92.
40-50 microliters/kg of Althesin were rapidly injected i.v. into 8 conscious neurosurgical patients on spontaneous ventilation (30-40 minutes after 0,5 mg atropine sulphate i.m.) for a total of 11 administrations. Electroencephalogram (EEG), intracranial pressure (PIC), systemic arterial blood pressure (PA) and central venous pressure (PVC) were continuously and simultaneously recorded. In four patients paCO2 was monitored. Slowing of EEG (accepted as an index of the brain metabolic depression) and lowering of the PIC occurred at the same time (P less than or equal to 0,001) and preceded the decrease in PA (P < 0,05) and in PVC (P < 0,05). These pressure changes were associated with both increases and decreases in paCO2. The data agrees with the hypothesis that the intracranial hypotensive effect of Althesin can be due to the induced metabolic brain depression through the secondary autoregulation of the cerebral blood flow (FEC).
将40 - 50微升/千克的阿耳忒辛快速静脉注射到8名自主呼吸的清醒神经外科患者体内（肌内注射0.5毫克硫酸阿托品30 - 40分钟后），共注射11次。连续同步记录脑电图（EEG）、颅内压（PIC）、体动脉血压（PA）和中心静脉压（PVC）。对4名患者监测了动脉血二氧化碳分压（paCO2）。脑电图减慢（被视为脑代谢抑制的指标）和颅内压降低同时出现（P≤0.001），且先于动脉血压（P < 0.05）和中心静脉压（P < 0.05）下降。这些压力变化与动脉血二氧化碳分压的升高和降低均有关。数据与以下假设一致：阿耳忒辛的颅内降压作用可能是由于通过脑血流的继发性自动调节（FEC）诱导脑代谢抑制所致。
