Clinical Laboratory, Central Laboratory, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao, 266000, People's Republic of China.
Department of Immunology, School of Basic Medicine, Qingdao University, No. 308 Ningxia Road, Qingdao, 266000, People's Republic of China.
Curr Atheroscler Rep. 2024 Nov 22;27(1):8. doi: 10.1007/s11883-024-01250-2.
RNA-binding proteins (RBPs) have emerged as crucial regulators of post-transcriptional processes, influencing the fate of RNA. This review delves into the biological functions of RBPs and their role in alternative splicing concerning atherosclerosis (AS), highlighting their participation in essential cellular processes. Our goal is to offer new insights for cardiovascular disease research and treatment.
Dysregulation of RBPs is associated with various human diseases, including autoimmune and neurological disorders. The role of RBPs in the pathogenesis of AS is progressively being elucidated, as they influence plaque formation and disease progression by regulating cell function and gene expression. RBPs play intricate biological roles in regulating pre-mRNA, including editing, splicing, stability and translation. Alternative splicing has been demonstrated to enhance biological complexity and diversity. Our findings indicate that alternative splicing is extensively involved in the pathogenesis of AS. The dysregulated expression of specific RBPs in AS is linked to the production of adhesion molecules and vascular endothelium damage. Further research on RBPs could pave the way for the development of novel therapeutic targets.
RNA 结合蛋白 (RBP) 已成为转录后过程的关键调节因子，影响 RNA 的命运。本文深入探讨了 RBPs 的生物学功能及其在动脉粥样硬化 (AS) 中的可变剪接中的作用，强调了它们在基本细胞过程中的参与。我们的目标是为心血管疾病的研究和治疗提供新的见解。
RBP 的失调与各种人类疾病有关，包括自身免疫和神经退行性疾病。RBP 在 AS 发病机制中的作用逐渐被阐明，因为它们通过调节细胞功能和基因表达影响斑块形成和疾病进展。RBP 在调节前体 mRNA 方面发挥着复杂的生物学作用，包括编辑、剪接、稳定性和翻译。可变剪接已被证明增强了生物复杂性和多样性。我们的研究结果表明，可变剪接广泛参与 AS 的发病机制。AS 中特定 RBP 的失调表达与黏附分子的产生和血管内皮损伤有关。对 RBPs 的进一步研究可能为开发新的治疗靶点铺平道路。
