Li Zheng, Chen Sainan, Wu Xuechao, Liu Fei, Zhu Jing, Chen Jiayi, Lu Xiaojie, Chi Rui
The Affiliated Wuxi No. 2 Hospital of Nanjing Medical University, Wuxi, China.
Nanjing Medical University, Nanjing, China.
Mol Cell Biochem. 2025 May;480(5):2707-2723. doi: 10.1007/s11010-024-05163-1. Epub 2024 Nov 22.
The metabolic reprogramming of amino acids is an important component of tumor metabolism. Branched-chain amino acids (BCAAs) perform important functions in tumor progression. They are the important amino donor and are involved in the synthesis of various non-essential amino acids, nucleotides, and polyamines to satisfy the increased demand for nitrogen sources. This review summarizes the studies related to abnormalities in BCAA metabolism during tumorigenesis and the potential therapeutic targets. The expression of BCAA transporters was significantly upregulated in tumor cells, which increases BCAA uptake. High expression of the BCAA transaminases is prevalent in various tumors, however, the dehydrogenation step of BCAA catabolism is inhibited in tumors. This review shows that BCAA metabolic reprogramming is an important tumor metabolic feature, and metabolic genes of BCAAs play a crucial role in tumor metabolism, representing a good auxiliary target for early clinical diagnosis and treatment. In addition, BCAAs are indispensable for maintaining immune system function, and dietary supplementation with BCAAs can enhance the activity of immune cells. Therefore, BCAA supplementation in tumor patients may affect the interaction between the immune system and tumors.
氨基酸的代谢重编程是肿瘤代谢的重要组成部分。支链氨基酸（BCAAs）在肿瘤进展中发挥重要作用。它们是重要的氨基供体，参与各种非必需氨基酸、核苷酸和多胺的合成，以满足对氮源增加的需求。本综述总结了与肿瘤发生过程中BCAA代谢异常及潜在治疗靶点相关的研究。BCAA转运体在肿瘤细胞中的表达显著上调，这增加了BCAA的摄取。BCAA转氨酶的高表达在各种肿瘤中普遍存在，然而，BCAA分解代谢的脱氢步骤在肿瘤中受到抑制。本综述表明，BCAA代谢重编程是一种重要的肿瘤代谢特征，BCAAs的代谢基因在肿瘤代谢中起关键作用，是早期临床诊断和治疗的良好辅助靶点。此外，BCAAs对维持免疫系统功能不可或缺，饮食中补充BCAAs可增强免疫细胞的活性。因此，肿瘤患者补充BCAAs可能会影响免疫系统与肿瘤之间的相互作用。
