Salim Anisha, Sathishkumar Palanivel
Green Lab, Department of Prosthodontics, Saveetha Dental College and Hospital, SIMATS, Saveetha University, Chennai 600 077, Tamil Nadu, India.
Green Lab, Department of Prosthodontics, Saveetha Dental College and Hospital, SIMATS, Saveetha University, Chennai 600 077, Tamil Nadu, India.
Int J Biol Macromol. 2024 Dec;283(Pt 4):137850. doi: 10.1016/j.ijbiomac.2024.137850. Epub 2024 Nov 27.
Antimicrobial resistance, the biggest issue facing the global healthcare sector, quickly emerged and spread due to the frequent use of antibiotics in regular treatments. The investigation of polymer-based nanomaterials as possible antibiofilm treatment agents is prompted by the growing ineffectiveness of conventional therapeutic techniques against these resistant bacteria species. So far, several articles have been published on microbial biofilm eradication using various polymer-based nanomaterials due to their therapeutic efficacy and biocompatibility nature. Despite their potential, a comprehensive review of the chitosan-based hybrid nanomaterials to treat microbial biofilms and their infections is lacking. This review provides a comprehensive investigation of the current state of therapeutic efficacy, various nanoformulations, advantages, limitations, and regulations of chitosan-based hybrid nanomaterials for biofilm treatment. Special attention is given to the application of chitosan-based nanomaterials in wound care, urinary tract infections, and dental biofilms are discussed, highlighting their role in managing biofilm-associated complications. Researchers will be better able to comprehend and develop unique, marketable chitosan-based nanomaterials with increased activity to treat biofilm infections in near future with the aid of this review.
抗菌耐药性是全球医疗保健行业面临的最大问题，由于在常规治疗中频繁使用抗生素，它迅速出现并传播开来。传统治疗技术对这些耐药菌种的有效性日益降低，这促使人们对基于聚合物的纳米材料作为可能的抗生物膜治疗剂进行研究。到目前为止，由于各种基于聚合物的纳米材料具有治疗功效和生物相容性，已经发表了几篇关于使用它们根除微生物生物膜的文章。尽管它们具有潜力，但缺乏对基于壳聚糖的混合纳米材料治疗微生物生物膜及其感染的全面综述。本综述全面研究了基于壳聚糖的混合纳米材料在生物膜治疗方面的治疗效果、各种纳米制剂、优点、局限性和相关规定的现状。特别关注了基于壳聚糖的纳米材料在伤口护理、尿路感染中的应用，并讨论了牙科生物膜，突出了它们在处理生物膜相关并发症中的作用。借助本综述，研究人员将能够在不久的将来更好地理解和开发具有更高活性的独特、适销对路的基于壳聚糖的纳米材料，以治疗生物膜感染。
