Tanaka Takashi, Morishita Shinichiro, Nakano Jiro, Inoue Junichiro, Okayama Taro, Suzuki Katsuyoshi, Osaki Keiichi, Fukushima Takuya
Department of Rehabilitation, Hyogo Medical University Hospital, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Department of Physical Therapy, Fukushima Medical University School of Health Sciences, Fukushima, Japan.
Int J Clin Oncol. 2025 Feb;30(2):252-266. doi: 10.1007/s10147-024-02659-0. Epub 2024 Nov 22.
This systematic review and meta-analysis aimed to investigate the association between health-related quality of life (HRQOL) as measured with the Short Form 36 Health Survey (SF-36) or Short Form 12 Health Survey (SF-12) and mortality risk in patients with diverse types of cancer.
A literature search was conducted using CINAHL, PubMed/MEDLINE, and Scopus databases to collect articles published before December 2022. Of these, observational studies that examined the association between HRQOL and mortality risk in patients with various cancer types were extracted. A subgroup analysis with a focus on the timing when HRQOL assessment was performed.
Nineteen studies were included in the final analysis. Through overall analysis of the timing of HRQOL measurements, most domains were found to be significantly associated with the mortality risk, irrespective of the timing of assessment, but HRQOL assessed in pre-treatment and palliative phases had particularly strong association.
In the present review, the physical functioning domain of HRQOL was found to be associated with mortality risk in a diverse group of cancer patients. This suggests the need for supportive care to improve HRQOL in cancer patients.
本系统评价和荟萃分析旨在研究使用简明健康状况调查36项量表（SF-36）或简明健康状况调查12项量表（SF-12）测量的健康相关生活质量（HRQOL）与不同类型癌症患者死亡风险之间的关联。
使用CINAHL、PubMed/MEDLINE和Scopus数据库进行文献检索，以收集2022年12月之前发表的文章。其中，提取了检验不同癌症类型患者HRQOL与死亡风险之间关联的观察性研究。进行了一项亚组分析，重点关注HRQOL评估的时间。
19项研究纳入最终分析。通过对HRQOL测量时间的总体分析，发现大多数领域与死亡风险显著相关，无论评估时间如何，但在治疗前和姑息治疗阶段评估的HRQOL关联尤为强烈。
在本综述中，发现HRQOL的身体功能领域与不同癌症患者群体的死亡风险相关。这表明需要提供支持性护理以改善癌症患者的HRQOL。
