一种快速可生物降解组织粘合剂：1,2-亚异丙基甘油基2-氰基丙烯酸酯的合成与生物评价
Synthesis and bioevaluation of a rapidly biodegradable tissue adhesive: 1,2-isopropylidene glyceryl 2-cyanoacrylate.
作者信息
Jaffe H, Wade C W, Hegyeli A F, Rice R M, Hodge J
出版信息
J Biomed Mater Res. 1986 Feb;20(2):213-7. doi: 10.1002/jbm.820200210.
PMID:3957959
Abstract
A rapidly biodegradable tissue adhesive, 1,2-isopropylidene glyceryl 2-cyanoacrylate, was synthesized and characterized by NMR. Bond strength was determined. Three types of corresponding polymers were prepared and evaluated for in vitro and in vivo toxicity. The polymers were generally found to be in the moderately toxic and toxic groups similar to the lower alkyl 2-cyanoacrylates.
摘要
合成了一种可快速生物降解的组织粘合剂1,2-亚异丙基甘油2-氰基丙烯酸酯，并通过核磁共振进行了表征。测定了其粘结强度。制备了三种相应的聚合物，并对其进行了体外和体内毒性评估。结果发现，这些聚合物通常与低级烷基2-氰基丙烯酸酯类似，属于中等毒性和毒性组。
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