Zhang Yizi, Yuan Jiahui, Mao Ting
Department of Agricultural and Biosystems Engineering, South Dakota State University, Brookings, SD, United States.
Alfred Dairy Science Laboratory, Department of Dairy and Food Science, South Dakota State University, Brookings, SD, United States.
Comp Biochem Physiol C Toxicol Pharmacol. 2025 Feb;288:110080. doi: 10.1016/j.cbpc.2024.110080. Epub 2024 Nov 22.
Microplastics (MPs) are significant concerns affecting liver health. This is the first comprehensive meta-analysis, evaluating the impact of MPs on liver functions across various animal models, including mice, fish, crabs, and shrimp. Five databases, including PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Ovid MEDLINE, and Web of Science, were used to select eligible studies. In all, 70 studies out of 1872 publications were included in the analysis, the impact of MPs on liver enzymes, oxidative stress markers, and inflammatory cytokines were evaluated. Our results revealed significant increases in liver enzymes ALT and AST, oxidative stress markers MDA, and pro-inflammatory cytokines IL-6 and TNF-α, along with a notable reduction in antioxidative enzymes like SOD, CAT, GSH, and GPx. These findings suggest that MPs exposure significantly disrupts liver function by inducing oxidative stress and inflammation. The results underscore the urgent need for targeted environmental policies and further research.
微塑料（MPs）是影响肝脏健康的重大问题。这是第一项全面的荟萃分析，评估了微塑料对包括小鼠、鱼类、螃蟹和虾在内的各种动物模型肝脏功能的影响。使用了五个数据库，包括PubMed、Embase、Cochrane对照试验中央注册库（CENTRAL）、Ovid MEDLINE和Web of Science，以选择符合条件的研究。总共从1872篇出版物中纳入了70项研究，评估了微塑料对肝酶、氧化应激标志物和炎性细胞因子的影响。我们的结果显示，肝酶ALT和AST、氧化应激标志物MDA以及促炎细胞因子IL-6和TNF-α显著增加，同时抗氧化酶如SOD、CAT、GSH和GPx显著减少。这些发现表明，接触微塑料会通过诱导氧化应激和炎症显著破坏肝脏功能。结果强调了制定针对性环境政策和进一步研究的迫切需要。
