Floyd R, Hughes N, O'Sullivan L, Hevey D, Murphy N, Hinds C, Owens L
Department of Obstetrics & Gynaecology, The Coombe Hospital, Dublin, Ireland.
Department of Psychology, Trinity College Dublin, Dublin, Ireland.
Ir J Psychol Med. 2024 Nov 25:1-5. doi: 10.1017/ipm.2024.56.
Women with polycystic ovary syndrome (PCOS) experience higher rates of depression and anxiety. There is limited research relating to perinatal mental health in women with PCOS. Studies suggest PCOS is associated with a higher prevalence of perinatal mental health disorders. Perinatal guidelines currently do not recognise PCOS as a risk factor for perinatal mental health disorders. We aimed to prospectively assess the prevalence of mental health disorders in pregnant women with PCOS.
Consenting pregnant women, with and without PCOS, were invited to participate. Standardised validated questionnaires were carried out including Generalised Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9) and Edinburgh Postnatal Depression Scale (EPDS).
Fifty-one with PCOS and 49 without PCOS responded. Pregnant women with PCOS had a higher mean (SD) anxiety score (GAD-7) than those without PCOS (8.2 [6.7] vs. 5.89 [4.7], = 0.04). Pregnant women with PCOS had higher mean (SD) depression scores than those without PCOS on EPDS (9.1 [6.4] vs. 6.4 [4.5], = 0.02) but not PHQ-9 score (median (IQR) 4 (3-9) vs. 4 (2-7.5), = 0.25). Women with PCOS were more likely to experience moderate/severe anxiety (PCOS 34%, control 20%) and moderate/severe depression (PCOS 34%, control 20%) symptoms than women without PCOS. Twenty-nine percent of pregnant women with PCOS had an EPDS score >13 showing significantly higher rates of severe depression (PCOS 29%, control 12%, = 0.03).
Our findings suggest a higher prevalence of perinatal depression and anxiety in women with PCOS. Our findings may suggest increased need for screening for mental health disorders in women with PCOS.
多囊卵巢综合征（PCOS）女性的抑郁和焦虑发生率较高。关于PCOS女性围产期心理健康的研究有限。研究表明，PCOS与围产期心理健康障碍的较高患病率相关。目前围产期指南未将PCOS视为围产期心理健康障碍的危险因素。我们旨在前瞻性评估PCOS孕妇心理健康障碍的患病率。
邀请了同意参与的患有和未患有PCOS的孕妇。进行了标准化的有效问卷调查，包括广泛性焦虑障碍量表-7（GAD-7）、患者健康问卷-9（PHQ-9）和爱丁堡产后抑郁量表（EPDS）。
51名患有PCOS的孕妇和49名未患有PCOS的孕妇做出了回应。患有PCOS的孕妇的平均（标准差）焦虑评分（GAD-7）高于未患有PCOS的孕妇（8.2[6.7]对5.89[4.7]，P=0.04）。在EPDS上，患有PCOS的孕妇的平均（标准差）抑郁评分高于未患有PCOS的孕妇（9.1[6.4]对6.4[4.5]，P=0.02），但在PHQ-9评分上无差异（中位数（四分位间距）4（3-9）对4（2-7.5），P=0.25）。与未患有PCOS的女性相比，患有PCOS的女性更有可能出现中度/重度焦虑（PCOS组34%，对照组20%）和中度/重度抑郁（PCOS组34%，对照组20%）症状。29%的患有PCOS的孕妇EPDS评分>13，显示重度抑郁发生率显著更高（PCOS组29%，对照组12%，P=0.03）。
我们的研究结果表明，PCOS女性围产期抑郁和焦虑的患病率较高。我们的研究结果可能表明，对PCOS女性进行心理健康障碍筛查的需求增加。
