Department of Obstetrics and Gynaecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.
Reproductive Endocrinology and Infertility Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Rajataewe, Bangkok, 10400, Thailand.
BMC Psychiatry. 2024 Nov 1;24(1):760. doi: 10.1186/s12888-024-06154-8.
Polycystic ovary syndrome (PCOS) is a common gynaecological problem for women of reproductive age. Depression and anxiety are common conditions that occur in women with PCOS and have an impact on mental well-being. However, there is a lack of data on their prevalence and its associated factors in the Thai population. This cross-sectional study aimed to evaluate the prevalence of depression and anxiety among women with PCOS and identify the factors associated with depression and anxiety in women with PCOS as well as their impact on mental well-being in Thailand.
A total of 260 women aged 15 to 40 years diagnosed with PCOS based on the Rotterdam criteria were included in the study. Physical examinations were conducted, and participants completed Hospital Anxiety and Depression Scale (HADS) and Thai version WHO-Five Well-Being Index (WHO-5 Thai) questionnaires to assess depression, anxiety, and mental well-being, respectively. The prevalence and prevalence rations (PR) with 95% confidence interval (CI) for depression and anxiety were analysed using modified Poisson regression analyses with robust variance estimators.
The prevalence of depression, anxiety, and poor mental well-being among women with PCOS was found to be 3.85%, 11.92%, and 16.92%, respectively. Abdominal obesity (PR 24.25, 95% CI: 2.75-219.50; p = 0.004), poor mental well-being (PR 16.68, 95% CI: 4.02-69.18; p = < 0.001), and snoring (PR 10.26, 95% CI: 2.06-51.14; p = 0.005) were identified as factors associated with depression in women with PCOS. Having children (PR 6.22, 95% CI: 2.90-13.35; p = < 0.001), alcohol drinking (PR 3.41, 95% CI: 1.52-7.65; p = 0.003), poor mental well-being (PR 2.32, 95% CI: 1.14-4.74; p = 0.021), and hirsutism (PR 2.23, 95% CI: 1.18-4.22; p = 0.014) were found to be relative factors for anxiety in women with PCOS.
Women with PCOS is associated with high prevalences of depression and anxiety. Poor mental well-being was identified as key factors associated with both depression and anxiety in women with PCOS. Based on these findings, the present study suggests that screening for depression and anxiety should be conducted for all women with PCOS, especially those who present with poor mental well-being.
多囊卵巢综合征（PCOS）是育龄妇女常见的妇科问题。抑郁和焦虑是 PCOS 患者常见的病症，会对心理健康产生影响。然而，泰国人群中 PCOS 患者抑郁和焦虑的患病率及其相关因素的数据还很缺乏。本横断面研究旨在评估泰国 PCOS 患者抑郁和焦虑的患病率，并确定 PCOS 患者抑郁和焦虑的相关因素及其对心理健康的影响。
共纳入 260 名年龄在 15 至 40 岁之间、根据 Rotterdam 标准诊断为 PCOS 的女性。进行体格检查，参与者完成医院焦虑和抑郁量表（HADS）和泰国版世界卫生组织五维健康指数（WHO-5 泰国）问卷，分别评估抑郁、焦虑和心理健康。使用修正泊松回归分析和稳健方差估计分析抑郁和焦虑的患病率和患病率比（PR）及其 95%置信区间（CI）。
PCOS 患者的抑郁、焦虑和心理健康不良的患病率分别为 3.85%、11.92%和 16.92%。腹型肥胖（PR 24.25，95%CI：2.75-219.50；p=0.004）、心理健康不良（PR 16.68，95%CI：4.02-69.18；p<0.001）和打鼾（PR 10.26，95%CI：2.06-51.14；p=0.005）被确定为 PCOS 患者抑郁的相关因素。有孩子（PR 6.22，95%CI：2.90-13.35；p<0.001）、饮酒（PR 3.41，95%CI：1.52-7.65；p=0.003）、心理健康不良（PR 2.32，95%CI：1.14-4.74；p=0.021）和多毛症（PR 2.23，95%CI：1.18-4.22；p=0.014）被认为是 PCOS 患者焦虑的相关因素。
PCOS 患者抑郁和焦虑的患病率较高。心理健康不良被确定为 PCOS 患者抑郁和焦虑的关键相关因素。基于这些发现，本研究建议对所有 PCOS 患者，尤其是心理健康不良的患者进行抑郁和焦虑筛查。
