White J M, Richards R, Jelenski G, Byrne M, Ali M
J Clin Pathol. 1986 Mar;39(3):256-9. doi: 10.1136/jcp.39.3.256.
The iron state was examined in two groups of pregnant women who were carriers of alpha and beta thalassaemia genes. In both groups the haematological expression of the disease--namely, haemoglobin and mean cell haemoglobin concentrations--was nearly identical. In patients with alpha thalassaemia the ferritin concentrations and percentage of ferritin deficiency was the same as in normal pregnant patients, whereas in those with beta thalassaemia the ferritin concentrations were usually much higher and iron deficiency four times less common. This variance appears to be explained by different degrees of extravascular or intravascular haemolysis between the two thalassaemias as assessed by the activities of serum alpha hydroxybutyrate dehydrogenase.
对两组携带α和β地中海贫血基因的孕妇的铁状态进行了检查。在两组中，疾病的血液学表现——即血红蛋白和平均细胞血红蛋白浓度——几乎相同。α地中海贫血患者的铁蛋白浓度和铁蛋白缺乏百分比与正常孕妇相同，而β地中海贫血患者的铁蛋白浓度通常要高得多，缺铁的情况则少四倍。这种差异似乎可以通过血清α羟丁酸脱氢酶活性评估的两种地中海贫血之间不同程度的血管外或血管内溶血来解释。
